A Review on Synthesis, Applications, Toxicity, Risk Assessment and Limitations of Plant Extracts Synthesized Silver Nanoparticles

Velidandi, Aditya; Dahariya, Swati; Pabbathi, Ninian Prem Prashanth; Divakar, K.; Baadhe, Rama Raju

doi:10.17756/nwj.2020-079

Cited by 34 publications

(20 citation statements)

References 193 publications

(203 reference statements)

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“…Due to their small size, AgNPs easily penetrate cellular and subcellular structures releasing Ag + responsible for deleterious effects such as increase in oxidative stress, DNA and RNA denaturation, blockage of electron transport chain and ATP formation. AgNPs showed toxicity against different cells and organisms, their toxicity being strongly dependent on size (particles less than 20 nm are highly toxic) and also on the shape, stability, and surface chemistry [ 1 , 68 ]. In the present study, the potential cytotoxic (antimitotic) and genotoxic effects of AgNPs and bark extracts used for their synthesis were evaluated using Allium cepa assay.…”

Section: Resultsmentioning

confidence: 99%

Phyto-Functionalized Silver Nanoparticles Derived from Conifer Bark Extracts and Evaluation of Their Antimicrobial and Cytogenotoxic Effects

et al. 2021

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Silver nanoparticles synthesized using plant extracts as reducing and capping agents showed various biological activities. In the present study, colloidal silver nanoparticle solutions were produced from the aqueous extracts of Picea abies and Pinus nigra bark. The phenolic profile of bark extracts was analyzed by liquid chromatography coupled to mass spectrometry. The synthesis of silver nanoparticles was monitored using UV-Vis spectroscopy by measuring the Surface Plasmon Resonance band. Silver nanoparticles were characterized by attenuated total reflection Fourier transform infrared spectroscopy, Raman spectroscopy, dynamic light scattering, scanning electron microscopy, energy dispersive X-ray and transmission electron microscopy analyses. The antimicrobial and cytogenotoxic effects of silver nanoparticles were evaluated by disk diffusion and Allium cepa assays, respectively. Picea abies and Pinus nigra bark extract derived silver nanoparticles were spherical (mean hydrodynamic diameters of 78.48 and 77.66 nm, respectively) and well dispersed, having a narrow particle size distribution (polydispersity index values of 0.334 and 0.224, respectively) and good stability (zeta potential values of −10.8 and −14.6 mV, respectively). Silver nanoparticles showed stronger antibacterial, antifungal, and antimitotic effects than the bark extracts used for their synthesis. Silver nanoparticles obtained in the present study are promising candidates for the development of novel formulations with various therapeutic applications.

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Section: Resultsmentioning

confidence: 99%

Phyto-Functionalized Silver Nanoparticles Derived from Conifer Bark Extracts and Evaluation of Their Antimicrobial and Cytogenotoxic Effects

et al. 2021

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“…Despite the highlighted potential of biosynthesized MNPs, very few of them have been critically evaluated for in vivo purposes [ 130 ] and only one was evaluated in human trials [ 73 ]. This suggests that many of the MNP formulations have not sufficiently accomplished the pharmaceutical regulation to warrant their clinical application [ 131 ].…”

Section: Biological Application Of Mnps Synthesized From Some Selected South African Medicinal Plantsmentioning

confidence: 99%

Green Synthesis of Metallic Nanoparticles Using Some Selected Medicinal Plants from Southern Africa and Their Biological Applications

Aboyewa

Sibuyi

Meyer

et al. 2021

Plants

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The application of metallic nanoparticles (MNPs), especially that of silver, gold, cobalt, and zinc as antimicrobial, anticancer, drug delivery, contrast, and bioimaging agents has transformed the field of medicine. Their functions, which are attributed to their physicochemical properties, have gained prominence in various technological fields. Although MNPs can be produced via rigorous physical and chemical techniques, in recent years, a biological approach utilizing natural materials has been developed. With the increasing enthusiasm for safe and efficient nanomaterials, the biological method incorporating microorganisms and plants is preferred over physical and chemical methods of nanoparticle synthesis. Of these bio-entities, plants have received great attention owing to their capability to reduce and stabilize MNPs in a single one-pot protocol. South Africa is home to ~10% of the world’s plant species, making it a major contributor to the world’s ecological scenery. Despite the documented contribution of South African plants, particularly in herbal medicine, very few of these plants have been explored for the synthesis of the noble MNPs. This paper provides a review of some important South African medicinal plants that have been utilized for the synthesis of MNPs. The enhanced biological properties of the biogenic MNPs attest to their relevance in medicine. In this endeavour, more of the African plant biodiversity must be explored for the synthesis of MNPs and be validated for their potential to be translated into future nanomedicine.

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“…The physicochemical properties of silver nanoparticles are largely determined by the synthesis conditions: temperature, reaction time, pH, molar ratio of reagents, order of addition of salts and reducing agents, speed and type of stirring, etc. [18]. For example, the AgNPs with a size of 18 ± 4 nm were synthesized at a temperature of 120 • C and a heating rate of 7.5 • C min −1 by the precursor heating method, where the main factor affecting particle size was heating rate.…”

Section: Synthesis and Self-assembly Of Biogenic Silver Nanoparticlesmentioning

confidence: 99%

“…In addition, this method provides a high concentration of silver colloids and can be applied in industrial production [32]. In the study of Behravan et al the influence of AgNO 3 concentration, extract concentration of Berberis vulgaris and reaction incubation time were identified for the biosynthesis of AgNPs [18].…”

Section: Synthesis and Self-assembly Of Biogenic Silver Nanoparticlesmentioning

confidence: 99%

Biogenic Silver Nanoparticles: Synthesis and Application as Antibacterial and Antifungal Agents

et al. 2021

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The importance and need for eco-oriented technologies has increased worldwide, which leads to an enhanced development of methods for the synthesis of nanoparticles using biological agents. This review de-scribes the current approaches to the preparation of biogenic silver nanoparticles, using plant extracts and filtrates of fungi and microorganisms. The peculiarities of the synthesis of particles depending on the source of biocomponents are considered as well as physico-morphological, antibacterial and antifungal properties of the resulting nanoparticles which are compared with such properties of silver nanoparticles obtained by chemical synthesis. Special attention is paid to the process of self-assembly of biogenic silver nanoparticles.

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A Review on Synthesis, Applications, Toxicity, Risk Assessment and Limitations of Plant Extracts Synthesized Silver Nanoparticles

Cited by 34 publications

References 193 publications

Phyto-Functionalized Silver Nanoparticles Derived from Conifer Bark Extracts and Evaluation of Their Antimicrobial and Cytogenotoxic Effects

Phyto-Functionalized Silver Nanoparticles Derived from Conifer Bark Extracts and Evaluation of Their Antimicrobial and Cytogenotoxic Effects

Green Synthesis of Metallic Nanoparticles Using Some Selected Medicinal Plants from Southern Africa and Their Biological Applications

Biogenic Silver Nanoparticles: Synthesis and Application as Antibacterial and Antifungal Agents

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