Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine and research, as well as in other varied sciences. Due to their unique size-dependent properties, lipid nanoparticles offer the possibility to develop new therapeutics. The ability to incorporate drugs into nanocarriers offers a new prototype in drug delivery that could be used for secondary and tertiary levels of drug targeting. Hence, solid lipid nanoparticles hold great promise for reaching the goal of controlled and site specific drug delivery and hence have attracted wide attention of researchers. This review presents a broad treatment of solid lipid nanoparticles discussing their advantages, limitations and their possible remedies. The different types of nanocarriers which were based on solid lipid like solid lipid nanoparticles, nanostructured lipid carriers, lipid drug conjugates are discussed with their structural differences. Different production methods which are suitable for large scale production and applications of solid lipid nanoparticles are described. Appropriate analytical techniques for characterization of solid lipid nanoparticles like photon correlation spectroscopy, scanning electron microscopy, differential scanning calorimetry are highlighted. Aspects of solid lipid nanoparticles route of administration and their biodistribution are also incorporated. If appropriately investigated, solid lipid nanoparticles may open new vistas in therapy of complex diseases.

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The herb Ashwagandha (Withania somnifera, Dunal), has been used for centuries in Ayurveda as rasayanapromoter of longevity, well-being, and disease prevention. Traditional use combines the herb with a carrier substance called "anupana," believed to help aid in bioavailability and absorption. To compare the effects of Ashwagandha root extract plus anupana on human immune activation to Ashwagandha extract without anupana, anupana plus sham extract, and sham extract only.

One may find difficulties with oral and parenteral drug delivery systems in a routine of clinical practice because they do not have sufficient compliance and bioavailability for patients. So, nowadays transdermal route is a greater area of interest of pharmaceutical research for delivering drug. But skin is the most challenging area to cross in transdermal delivery of drug as the stratum corneum & the outer layer of the skin have tight intracellular junctions. Researchers have developed various approaches like micro needle, sonophoresis, electrophoresis, and iontophoresis etc to overcome those complications for the transdermal delivery of drugs. Chemical permeation enhancers are needed in vesicular drug delivery system such as niosomes, liposomes, elastic liposomes (transfersomes and ethosomes) to improve their penetration property. Transferosomes can be prepared by a number of methods like vortexing, sonication method, freeze–thaw method, ethanol injection method, Reverse-phase evaporation method, etc. Transfersomes can carry wide ranges of drugs having a wide range of solubility within it as they are constructed of hydrophobic as well as hydrophilic moieties. The main property of transferosome is deformability. This flexible nature of the vesicle membrane helps transfersome to go across the narrow pores with a maximum amount of drugs present within it. They have high deformable capacity which exhibits advanced penetration capability of intact vesicles. Both high and low molecular weight drugs like albumin, insulin, corticosteroids, sex hormones, anesthetic, anticancer, analgesic can be fused within transfersome.

In the recent era, developments in the field of bio-inorganic chemistry have improved interest in Schiff base complexes (imine scaffolds) for their pharmacological excellence in different areas. Schiff bases are a kind of synthetic molecule that is synthesized by the condensation reaction between a 1o amine and a carbonyl compound. Imine derivatives are also acknowledged for their ability to form complexes with several metals. Due to their wide range of biological activities, they have acquired prominence in the therapeutic and pharmaceutical industries. Inorganic chemists have continued to be intrigued by the vast range of uses of these molecules. Many of them are also thermally stable and have structural flexibility. Some of these chemicals have been discovered to be beneficial as clinical diagnostic agents as well as chemotherapeutic agents. Because of the flexibility of the reactions, these complexes have a wide range of characteristics and applications in biological systems. Anti-neoplastic activity is one of them. This review attempts to draw attention to the most notable examples of these novel compounds, which have excellent anticancer activity against different cancers. The synthetic scheme of these scaffolds, their metal complexes, and the explanation of their anticancer mechanism reported in this paper lead the researchers to design and synthesize more target-specific Schiff base congeners with little or no side effects in the future.