Solid lipid nanoparticles: A modern formulation approach in drug delivery system

Abstract

Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine and research, as well as in other varied sciences. Due to their unique size-dependent properties, lipid nanoparticles offer the possibility to develop new therapeutics. The ability to incorporate drugs into nanocarriers offers a new prototype in drug delivery that could be used for secondary and tertiary levels of drug targeting. Hence, solid lipid nanoparticles hold great promise for reaching the goal of controlled and site specific drug delivery and hence have attracted wide attention of researchers. This review presents a broad treatment of solid lipid nanoparticles discussing their advantages, limitations and their possible remedies. The different types of nanocarriers which were based on solid lipid like solid lipid nanoparticles, nanostructured lipid carriers, lipid drug conjugates are discussed with their structural differences. Different production methods which are suitable for large scale production and applications of solid lipid nanoparticles are described. Appropriate analytical techniques for characterization of solid lipid nanoparticles like photon correlation spectroscopy, scanning electron microscopy, differential scanning calorimetry are highlighted. Aspects of solid lipid nanoparticles route of administration and their biodistribution are also incorporated. If appropriately investigated, solid lipid nanoparticles may open new vistas in therapy of complex diseases.

Enhancing biopharmaceutical attributes of phospholipid complex-loaded nanostructured lipidic carriers of mangiferin: Systematic development, characterization and evaluation

“…Indeed, nanocarriers such as lipid micelles (Neuberg et al, 2015), solid lipid nanoparticles (Mukherjee et al, 2009;Bunjes, 2010), nanostructured lipidic carriers (NLCs) (Khan et al, 2015) and lipid nanocapsules (Sánchez-Moreno et al, 2012) have already been reported to hold immense promise for oral delivery of poorly water-soluble bioactives. Amongst these nanocarriers, the NLCs are considered to be of wider interest owing to their high drug-loading efficiency and drug stability (Naseri et al, 2015;Shah et al, 2016).…”

Malign plevral mezotelyomada ilaç taşıyıcı nanosistemler

“…KLN'ler güvenli ve etkili bir şekilde gen ve ilaç türevi taşıyabilen nanotaşıyıcılardır. Diğer taşıyıcı sistemlere göre; lipofilik ve hidrofilik ilaçlarla kolaylıkla birleşebilme, gelişmiş fiziki stabiliteye sahip olma, kontrollü ilaç ve gen serbestlenmesini sağlama, biyolojik uyumluluk, bölgeye spesifik ilaç etkinliği gibi birçok avantajları sahip olduğundan, önemli bir nanotaşıyıcı olarak gösterilmektedir (44).…”

Lipid Nanoparticles for Ocular Drug Delivery

“…The common excipients used in SLN formulation are solid lipids, emulsifiers, co-emulsifiers and water [46] . They display major advantages such as controlled release, improved bioavailability, protection of chemically labile molecules, cost effective excipients, enhanced drug incorporation and extensive application range [47] . SLNs represent an interesting alternative to traditional colloidal carriers, such as emulsions, liposomes and polymeric nanoparticles.…”