Medicinal plants with potential therapeutic activities are a tremendous resources of prospective drug candidates. NSAIDs, opiates, and other anti-inflammatory & analgesic agents exhibit several unwanted side-effects. Thus, the development of new active compounds with minimum adverse effects necessitates an emergence. This study aims to provide a comprehensive summary of plant species and reported phytoconstituents with analgesic and inti-inflammatory activities. Eighty-seven species from fifty-two plant families with reported constituents and activities have been included in this review. In-depth research in the area of screening novel analgesic and antiinflammatory agents from natural sources followed by the investigation of their pharmacological properties and clinical applications may lead to the generation of new active agents with better therapeutic activity and selectivity in the future.
Dhaka Univ. J. Pharm. Sci. 19(2): 207-224, 2020 (December)
The chirality introduced at the C1 position of 1-substituted-1,2,3,4-tetrahydroisoquinolines, obtained by four methods of enantioselective reduction of 1-substituted-3,4-dihydroisoquinolines, are vital for various biological activities.
Aim: To evaluate the household iodine content and knowledge, attitude, and behavior regarding salt iodization among the residents of Cumilla, Bangladesh.
Subjects and Methods: We conducted a cross-sectional survey of 700 inhabitants in Cumilla's urban and rural areas to determine the iodine concentration of salt they consume. The participants were asked about what they know about iodine deficiency and salt iodization as well as how their salt was packaged and stored. Among them, 338 people provided a sample of salt to be tested of its iodine content by the titrimetric method.
Results: 46.57% of people knew that iodization was the best way to prevent iodine deficiency while 35.14% considered salt iodization during purchasing. Most people stored salt in plastic boxes (89.7%) and closed containers (84.14%).Among all participants, only 37.14% of people were aware of the iodine requirement during pregnancy.
In urban regions, the median iodine content was 36.76 ppm (OR=0.658, 95% CI, 0.469-0.925), while in rural areas, the median iodine content was 40.92 ppm (OR=1.188, 95% CI, 1.022-1.380). Iodine levels were less than 15 ppm (minimum limit) in 6.8% of samples and greater than 40 ppm (maximum limit) in 56.5%. Only 36.7% of the salt samples contained adequate iodine.
Conclusion: An effective and consistent approach for controlling iodine concentration in distributed salt is required at Cumilla, Bangladesh.
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