Introduction of chirality at C1 position of 1-substituted-3,4-dihydroisoquinoline by its enantioselective reduction: synthesis of chiral 1-substituted-1,2,3,4-tetrahydroisoquinoline – a review

Abstract

The chirality introduced at the C1 position of 1-substituted-1,2,3,4-tetrahydroisoquinolines, obtained by four methods of enantioselective reduction of 1-substituted-3,4-dihydroisoquinolines, are vital for various biological activities.