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Introduction: Physiological cyclic variability in levels of sex hormones during a menstrual cycle may possibly have an impact on lipids, lipoprotein levels and therefore on cardiovascular health status of females. Aim:To ascertain the effect of menstrual cycle phases on the levels of cardiovascular risk predictors i.e., plasma lipids and lipoproteins in healthy menstruating women.

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Topical metronidazole (10%) and sucralfate (7%) cream has been previously demonstrated to decrease postoperative pain after hemorrhoidectomy. The aim of this study was to evaluate the effect of topical metronidazole(10%) and sucralfate (7%) cream in reducing postoperative and after defecation pain of hemorrhoidectomy. A total of 60 patients aged 25-65 Years were studied. Patient were divided into 2 group patient in group A received topical metronidazole (10%) and sucralfate (7%) in group B received placebo (petrolatum cream) pain was assessed using a visual analog scale preoperatively and postoperative hours 5 hrs, 10 hrs and days 1, 3, 7, 14 the use of narcotics, analgesics and complication were recorded. Patient in group A had significantly less postoperative pain than those in group-B upto 14 days (p<.04) in group-A after defecation pain was ranked significantly lower at day 3. Patient required lesser analgesics postoperatively on day 3 and 7 (P<.04) We concluded that topical (10%) metronidazole and (7%) sucralfate significantly reduce post hemorrhoidectomy pain and postoperative defecation pain compared with that of the placebo control group.

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Background: C-reactive protein (CRP) is one of the most commonly employed indicator of acute phase reaction and predictors of cardiovascular disease in healthy women; although, only a sparse information on its variations during a regular menstrual cycle is currently available. Our objective was to see whether CRP levels are affected during different phases of menstrual cycle.Methods: Females aged 15-45 years with regular menstrual cycle in terms of length, flow and variation from cycle to cycle were followed for one menstrual cycle. Serum levels of C-reactive protein were measured in the Follicular (10th day) and in the Luteal (22nd day) phase of the menstrual cycle.Results: C-reactive protein levels were observed to vary in response to the phases of menstrual cycle. The concentrations of C-reactive protein levels tend to be highest during the Follicular phase and it declined significantly in the Luteal phase.Conclusions: Identifying the fluctuations in C-reactive protein levels during the menstrual cycle is essential as there may be clinical implication of the suitable timing of assessment while framing and concluding studies in women of reproductive age.

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