The Ominous Link between Obesity and Abdominal Adiposity with Diabetes and Diabetic Dyslipidemia in Diabetic Population of Developing Country

Sankhla, Manisha; Sharma, Tarun; Gahlot, Sushila; Rathor, Jai Singh; Vardey, Satish Kumar; Sinha, Maheep; Kaushik, G.G.; Gadhok, Amita K; Ghalaut, Veena Singh; Mathur, Keerti; Rg, Singh

doi:10.7754/clin.lab.2012.120317

Cited by 6 publications

(5 citation statements)

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“…An extensive screening based study on 19,072 persons with diabetes suggest a trend toward more number of younger persons, particularly women being diabetic from the rural areas , which parallels with our present result (t ¼ 2.983, p50.004 and 2 ¼ 12.86, p50.002). Report suggests that BMI is a strong predictor of fasting plasma glucose and glycaemic control (Sankhla et al, 2013) which is evident in our investigation ( Figure 2). The negative association of steroids viz.…”

Section: Discussionsupporting

confidence: 62%

Diabetes in rural individuals of different nutritional status and the alarming situation demands focus more on its under-nutrition association

Maiti

Sinha²,

Khan³

et al. 2014

Archives of Physiology and Biochemistry

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Section: Discussionsupporting

confidence: 62%

Diabetes in rural individuals of different nutritional status and the alarming situation demands focus more on its under-nutrition association

Maiti

Sinha²,

Khan³

et al. 2014

Archives of Physiology and Biochemistry

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“…After showing that B cells in the obese AT are autoimmune B cells with the phenotype T-bet+CD21 low CD95+, and in pannus more than in breast ( Fig 3 ), we wanted to measure secretion of autoimmune IgG in culture supernatants of unstimulated SVF samples. We tested 3 different autoimmune specificities: double strand (ds)DNA, malondehyldehyde (MDA) and adipocyte-derived antigens, which are associated with increased DNA damage (measured by dsDNA) [ 57 ], increased oxidative stress and lipid peroxidation (measured by MDA) [ 58 , 59 ], and increased fat mass [measured by adipocyte (AD)-derived protein antigens released by the tissue] [ 18 ]. We have previously shown that the AT of individuals with obesity is enriched in IgG autoimmune antibodies with specificity for AD-derived protein antigens [ 18 ], not known as typical autoantigens but released in large amounts without exogenous stimulation, due to chronic cell death in the AT and consequent release of “self” antigens able to induce continous activation of B cells without the need of additional stimulation [ 56 ].…”

Section: Resultsmentioning

confidence: 99%

Phenotypic and functional features of B cells from two different human subcutaneous adipose depots

et al. 2023

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In this study, we have compared frequencies, phenotype, function and metabolic requirements of B cells isolated from the breast and abdominal subcutaneous adipose tissue (AT) of women with obesity who underwent weight reduction surgeries. Results show that B cells from the abdominal AT are more inflammatory than those from the breast, characterized by higher frequencies of inflammatory B cell subsets and higher expression of RNA for inflammatory markers associated with senescence. Secretion of autoimmune antibodies is also higher in the abdominal AT as compared to the breast, and is associated with higher frequencies of autoimmune B cells with the membrane phenotype CD21lowCD95+ B cells expressing the transcription factor T-bet. Moreover, glucose uptake is higher in B cells from the abdominal AT as compared to the breast, thereby suggesting a better capacity to perform glycolysis, needed to support intrinsic B cell inflammation and autoimmune antibody secretion.

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“…Systemic oxidative stress is associated with abdominal obesity and insulin resistance 57,58) . Along withoxidativestress,chroniclow-intensityinflammation is clinically evident in obese 59) and insulin-resistant subjects 60) , manifesting as increased levels of inflammatorybiomarkers,suchasC-reactiveprotein, TNFα,IL6andfibrinogen.…”

Section: Obesity and Metabolic Syndrome: Relationships Between Insulimentioning

confidence: 99%

Antioxidant Effects of Statins in the Management of Cardiometabolic Disorders

Lim

Barter

2014

JAT

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Redox systems are key players in vascular health. A shift in redox homeostasis-that results in an imbalance between reactive oxygen species (ROS) generation and endogenous antioxidant defenses has the potential to create a state of oxidative stress that subsequently plays a role in the pathogenesis of a number of diseases, including those of the cardiovascular and metabolic system. Statins, which are primarily used to reduce the concentration of low-density lipoprotein cholesterol, have also been shown to reduce oxidative stress by modulating redox systems.Studies conducted both in vitro and in vivo support the role of oxidative stress in the development of atherosclerosis and cardiovascular diseases. Oxidative stress may also be responsible for various diabetic complications and the development of fatty liver. Statins reduce oxidative stress by blocking the generation of ROS and reducing the NAD＋/NADH ratio. These drugs also have effects on nitric oxide synthase, lipid peroxidation and the adiponectin levels.It is possible that the antioxidant properties of statins contribute to their protective cardiovascular effects, independent of the lipid-lowering actions of these agents. However, possible adverse effects of statins on glucose homeostasis may be related to the redox system. Therefore, studies investigating the modulation of redox signaling by statins are warranted. J Atheroscler Thromb, 2014; 21:997-1010.

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The Ominous Link between Obesity and Abdominal Adiposity with Diabetes and Diabetic Dyslipidemia in Diabetic Population of Developing Country

Cited by 6 publications

References 0 publications

Diabetes in rural individuals of different nutritional status and the alarming situation demands focus more on its under-nutrition association

Diabetes in rural individuals of different nutritional status and the alarming situation demands focus more on its under-nutrition association

Phenotypic and functional features of B cells from two different human subcutaneous adipose depots

Antioxidant Effects of Statins in the Management of Cardiometabolic Disorders

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