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Predicting and designing system with dynamic self-assembling property in spatiotemporal fashion is an important research area across disciplines ranging from understanding fundamental non-equilibrium features of life to fabrication of next-generation...

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The self assembly and structural modification of a γ-amino butyric acid based derivative in different solvents were studied and the structural variations were characterized using FE-SEM, confocal microscopy and computational methods.

Rationalizing changes in functional properties by an exogenous module in a synthetic nanoscale self-organized system has broader significance in designing responsive biomimic materials having application in catalysis to therapeutics. Herein, we have developed a substrate-driven nanoscale vesicular assembly of a metallosurfactant (with dipicolylamine co-ordinated with zinc ion as headgroup) which simultaneously acts as a cooperative catalyst for the hydrolysis of the RNA-model substrate, 2-hydroxypropyl-4nitrophenylphosphate (HPNPP). We have found out that both purine and pyrimidine-based nucleoside monophosphates interact differently with the assembly, modulating the rate of catalytic cleavage. The different means of recognition of the nucleobases leads to alteration in membrane fluidity as well as surface charge of the vesicular aggregates whether the assembly is in catalytically active or inactive state. Then a systematic pattern for different nucleotides mediated vesicular nanoscale assembly composed of a catalytically-active surfactant by statistically corelating alteration in dynamic membrane parameters (fluidity, surface charge) with its cooperative phosphodiester hydrolyzing ability has been generated using principal component analysis as statistical tool. Overall, it showed a unique response pathway of a cooperative functional assembly to different exogenous modules, and this perception of the deconvolution of collective property opens up an avenue for future development of advanced adaptive systems.

Selenide derivatives of imidazo[1, 2-a]pyridyl heterocyclic system have been investigated for their potential to generate novel and diverse self-assembled architectures. The effect of structural modification as well as insertion of...