Self-assembly of aromatic α-amino acids into amyloid inspired nano/micro scaled architects

Self-assembly of l-phenylalanine amino acid: electrostatic induced hindrance of fibril formation

“…Similar observations were also observed previously by other research groups in their TGA thermograph. 66,67 A signicant change in the weight is observed only above 330 C for the ake sample in comparison to the value of 225 C noticed for the sample responsible for bril structure (pH 5.8). In addition, surprisingly the value of weight loss attains only around $49% at temperature 367 C where a signicant weight loss was observed for L-Phe sample prepared from pH 5.8.…”

“…The weight as a function of temperature for the L-Phe sample prepared from pH 5.8 (black line) stays quite stable up to a temperature at around 225 C. However, subsequently the behavior of the plot changed signicantly with the weight loss followed with a plateau at around 290 C. At around 367 C temperature the weight loss reached a value of 99% with complete weight loss at above 430 C. The observed weight loss behavior of L-Phe sample as a function of temperature is quite similar to the results reported in the literature. 48,66 Interestingly, the TGA plot for the L-Phe powder sample prepared from pH 12.2 aqueous solution behaves very differently (red line). The initial small weight loss of 6% is observed above 70 C which is generally attributed towards the evaporation of solvent water molecules trapped in the sample.…”

“…2,23 This is quite apparent from many studies where the pH induced electrostatic interaction have played a vital role in the self-assembly process of various biological macromolecules for controlling the shape of the nanostructures. 21,66,[75][76][77] The perturbation in the aromatic stacking interaction can be achieved by enhancing other interactions such as intermolecular hydrogen bonding and electrostatic interaction. As a consequence, the outcome of the selfassembly bril morphology can be controlled to produce diverse assembled architectures.…”

Amino Acid Based Self‐assembled Nanostructures: Complex Structures from Remarkably Simple Building Blocks

“…[36] Increasing the proportion of methanol, thereby decreasing dielectric constant of the solvent mixture resulted in different nanostructures. Phe formed more ordered fibers with a smaller diameter when methanol content was increased.…”

Dynamics of amyloid-like aggregation and gel formation of hen egg-white lysozyme in highly concentrated ethanol solution

“…Recently, amyloid fiber formation has been investigated using various techniques including far-UV CD [11][12][13][14][15], IR absorption [13][14][15][16][17][18], nuclear magnetic resonance (NMR) *E-mail: rkita@keyaki.cc.u-tokai.ac.jp spectroscopy [16,19,20], and small-angle X-ray and neutron scattering [10,21,22]. Although these spectroscopic techniques yield detailed information about the structures of protein molecules, they cannot provide information about their state of aggregation.…”