The results of this study strongly indicate the protective effect of SCLE against CCl(4) induced acute liver toxicity in rats and thereby scientifically support its traditional use.

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In current study, we accepted out a systematic record of the relative antioxidant activity in selected medicinal plant species extracts. The total phenol varied from 25.3±7 to 278.4±7 mg g-1 in the extracts. Flavonoid contents were between 56±4.4 and 80.3±3.7. 1, 1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging result of the extracts was determined spectrophotometrically. The maximum radical scavenging consequence was observed in Metha pulegiam (Lamiacea) with IC50 = 0.018 mg ml-1. The strength of radical scavenging power of Metha pulegiam extract was about 4 times better than synthetic antioxidant butylated hydroxy toluene (BHT). The superior amount of phenolic compounds leads to further potent radical scavenging result as shown by Metha pulegiam leaves extract.

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Sida cordata (Burn. f.) Borss. Waalk is highly distributed in entire part of India. The various parts of the plant are used in folklore medicine for the management of multiple diseases.  So,the present study was performed to examine the  hepatoprotective activity study of ethanolic extract of S. cordata leaves (SCLE) on alcohol mediated  hepatotoxicity in a rat model. Ethanol intoxicated rats showed noteworthy elevation of liver weight and volume. Further, ethanol insulted rats also showed significant elevation in the level of biochemical markers such as AST, ALT, TG, TB, and DB) and marked variation in the histological structure of liver. Oral administration of SCLE at the dose of 200 and 400 mg/kg for 30 days) significantly reduced the liver weight, hepatic markers level and restored the histological changes annoyed by ethanol thus indicating its hepatoprotective potential. Furthermore, HPTLC analysis was performed for the identification and quality estimation of S. cordata leaves.