Protective effect of Sida cordata leaf extract against CCl4 induced acute liver toxicity in rats

Mistry, Sunil; Dutt, K. R.; Jena, Jyotirmoyee

doi:10.1016/s1995-7645(13)60057-7

Cited by 24 publications

(16 citation statements)

References 11 publications

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“…Its roots are used as diuretic, astringent, stomachic, febrifuge, and demulcent and seeds are applied as laxative, aphrodisiac, and demulcent, recommended in cystitis, colic, gonorrhea, tenseness, and piles [13]. The drug is useful in neurological disorders such as hemiplegia, facial paralysis, sciatica, general debility, headache, ophthalmia, dysuria, leucorrhoea, tuberculosis, diabetes, fever, rheumatism, and uterine disorders [14, 15]. Shah et al [16] reported its phytochemical, cytotoxic, and in vitro antileishmanial activity.…”

Section: Introductionmentioning

confidence: 99%

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Antidiabetic Effect ofSida cordatain Alloxan Induced Diabetic Rats

Shah

Khan

2014

BioMed Research International

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Medicinal plants are efficient ameliorator of oxidative stress associated with diabetes mellitus. In this study, ethyl acetate fraction (SCEE) of Sida cordata was investigated for scientific validation of its folk use in diabetes. Antidiabetic effect of SCEE was confirmed by antihyperglycemic activity in normal glucose loaded and diabetic glucose loaded animals as well as normal off feed animals. Confirmation of antidiabetic activity and toxicity ameliorative role of S. cordata was investigated in a chronic multiple dose treatment study of fifteen days. A single dose of alloxan (120 mg/kg) produced a decrease in insulin level, hyperglycemia, elevated total lipids, triglycerides, and cholesterol and decreased the high-density lipoproteins. Concurrent with these changes, there was an increase in the concentration of lipid peroxidation (TBARS), H2O2, and nitrite in pancreas, liver, and testis. This oxidative stress was related to a decrease in glutathione content (GSH) and antioxidant enzymes. Administration of SCEE for 15 days after diabetes induction ameliorated hyperglycemia, restored lipid profile, blunted the increase in TBARS, H2O2, and nitrite content, and stimulated the GSH production in the organs of alloxan-treated rats. We suggested that SCEE could be used as antidiabetic component in case of diabetes mellitus. This may be related to its antioxidative properties.

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Section: Introductionmentioning

confidence: 99%

“…Shah et al [16] reported its phytochemical, cytotoxic, and in vitro antileishmanial activity. Mistry et al [15] and Shah et al [17] reported S. cordata antioxidant potential as hepatoprotective against CCl 4 induced toxicity in rat. Shah et al [17] described ethyl acetate fraction as strong antioxidant component.…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic Effect ofSida cordatain Alloxan Induced Diabetic Rats

Shah

Khan

2014

BioMed Research International

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“…Hepatotoxicity test model induced by CCl 4 was used with slight modification [16,17] . Liver toxicity was induced by i.p.…”

Section: Hepatoprotective Activity Assaymentioning

confidence: 99%

Preclinical Evaluation of Scorzonera sp. Root Extracts and Major Compounds Against Acute Hepatotoxicity Induced by Carbon Tetrachloride

Acikara¹,

Yigitbasi²,

Sakul³

et al. 2017

pharmaceutical-sciences

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Evaluation of hepatoprotective activities of Scorzonera roots and their major compounds, was aimed in current study. Scorzonera latifolia, S. tomentosa, S. mollis ssp. szowitsii, S. parviflora and S. cana var. jacquiniana roots, methanol-water (80:20) extracts together with chlorogenic acid, scorzotomentosin-4'-O-β-glucoside, hydrangenol-8-O-β-glucoside as major compounds isolated from S. latifolia roots were tested for their hepatoprotective activities. Sprague Dawley rats were used for experiment and hepatotoxicity was induced by carbon tetrachloride. Aspartate aminotransferase and alanine aminotransferase levels were measured and all results were confirmed by histopathological examination. Plasma aspartate aminotransferase and alanine aminotransferase levels of examined groups were not significant when compared to carbon tetrachloride-treated groups. However histopathological results have revealed that all tested groups have less damage when compared to carbon tetrachloride group except scorzotomentosin-4'-O-β-glucoside and hydrangenol-8-O-β-glucoside groups. Scorzonera species displayed moderate hepatoprotective activities against carbon tetrachloride induced acute toxicity. Chlorogenic acid, among tested compounds exhibited higher activity than all tested Scorzonera species as well as other isolated compounds. Therefore chlorogenic acid could be suggested as responsible compound.

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“…The Hepatoprotective activity was evaluated in Wister albino rats using CCl 4 induced liver injury (Mistry et al, 2013). The rats were divided into seven groups (n=5); Group-1 served as control (normal saline), Group II served as hepatotoxic (CCl 4 ), Group III, served as positive control (Silymarin).…”

Section: Hepatoprotective Studymentioning

confidence: 99%

Comparative Anti-Inflammatory and Hepatoprotective Activities of <i>Astragalus Gummifer</i> Labill Herb and Roots in Rats

Yusufoğlu¹,

Alam²,

Zaghloul³

et al. 2014

Afr. J. Trad. Compl. Alt. Med.

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Background: The Astragalus gummifer (F. Fabaceae), herb and roots were studied for anti-inflammatory and hepatoprotective activities. Materials and method:The alcoholic extracts of Astragalus gummifer (F. Fabaceae), herb (AGHE), and roots (AGRE), were used for antiinflammatory and hepatoprotective activities in Wister rats. The effects of AGHE and AGRE were compared with the standard drugs Phenylbutazone and silymarin, for anti-inflammatory and hepatoprotective activities respectively. Result: Both extracts showed significant anti-inflammatory activity (P< 0.001). AGRE showed comparatively more significant hepatoprotective activity (P< 0.001), than AGHE (P< 0.05); at doses of 250 and 500 mg/kg body weight as manifested by lowering the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), and total bilirubin. The hepatoprotective activity was, also, supported by total protein (TP), malondialdehyde (MDA), nonprotein sulfhydryls (NP-SH), and histo-pathological studies of liver tissue. Discussion: To the best of our knowledge, this is the first report of the anti-inflammatory and hepatoprotective activities of Astragalus gummifer.The results of present studies indicated that both AGHE and AGRE can be used in inflammatory conditions, while investigation supports the use of AGRE in cases that hepatoprotection are required in the hepatotoxic conditions. More supportive studies are required before clinical recommendation.

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Protective effect of Sida cordata leaf extract against CCl4 induced acute liver toxicity in rats

Abstract: The results of this study strongly indicate the protective effect of SCLE against CCl(4) induced acute liver toxicity in rats and thereby scientifically support its traditional use.

Cited by 24 publications

References 11 publications

Antidiabetic Effect ofSida cordatain Alloxan Induced Diabetic Rats

Antidiabetic Effect ofSida cordatain Alloxan Induced Diabetic Rats

Preclinical Evaluation of Scorzonera sp. Root Extracts and Major Compounds Against Acute Hepatotoxicity Induced by Carbon Tetrachloride

Comparative Anti-Inflammatory and Hepatoprotective Activities of <i>Astragalus Gummifer</i> Labill Herb and Roots in Rats

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