An easy, perfect, specific, and accurate process has been studied for the estimation of acarbose pure drug form, as well as, tablet dosage forms. Using methanol as a solvent, acarbose has absorbance maxima at 206 nm, and this drug shows a linear response according to Beer’s law in the concentration range of 24 to 40 μg/mL. The outcomes of the study were validated statistically, and recovery studies were satisfactory as per ICH guidelines. Thus, the projected method can be proficiently useful for the estimation of acarbose in regular analysis effort.
Tramadol, an opioid analgesic, is used to relieve mild to moderately severe pain. It initially binds to the opioid receptor, and then it lessens the reactivity of norepinephrine and serotonin. The polymers EC, HPMC K4M, and CAP were encapsulated using the emulsion solvent evaporation process, and formulation characterization was completed. The obtained microspheres were round and white. The phosphate buff er with a pH of 6.8 was used for the in vitro investigations of the microspheres, which were carried out for 8 hours at a temperature of 37????C and 100 rpm in a 900 mL USP basket-type dissolution rate test equipment. Formulation F3 entrapped the most medication, but Formulation F6 displayed a greater yield. The impact of the polymer’s type and composition on the medication release was evident. The tramadol hydrochloride microsphere’s regulated drug release results in increased plasma drug content as well as better-quality bioavailability
A rapid and efficient flash chromatographic process for selective isolation of embelin from Embelia ribes was developed. The rate of extraction and purity of embelin depends upon the solvent used for extraction and optimized chromatographic separation. Ethyl acetate was found to be best solvent for highest possible recovery of the embelin from Embelia ribes. Flash chromatography speed up the purification process for quicker results. The purified sample of embelin was then characterized by UV, HPTLC, NMR and Mass.
Objective: An easy, perfect, specific and exact process has been studied for the simultaneous estimation of Glimepiride pure drug form as well as tablet dosage forms. Methods: A UV method for quantitative evaluation of Glimepiride by first order derivative peak detect method for determination in bulk as well as tablet dosage form is reported as there was a need to expand novel methods to analyze the drug. Results: Glimepiride has absorbance first derivative maxima at 225 nm in Methanol. Glimepiride follows Beer’s law in concentration range of 5-25µg/ml. The outcomes of the study were validated statistically and recovery studies were performed as per ICH guide lines. Conclusion: Thus the projected method can be applied competently for the estimation of Glimepiride in regular analysis in its dosage forms.
In the present study, an attempt has been made to develop an analytical method for the simultaneous estimation of gallic acid and embelin in marketed Ayurvedic polyherbal formulation Avipathi choornam by High Performance Liquid Chromatography (HPLC). The chromatographic separation was performed on Hemochrom C18 column (250 mm L × 4.6 mm ID column: packing size- 5 μm) with a mobile phase methanol: phosphate buffer pH 3.3 (adjusted with glacial acetic acid) in 75:25 V/V proportion at flow rate of 0.8 mL/min. The analysis was carried out in the absorbance mode at 291 nm. Gallic acid and embelin were satisfactorily resolved with Rt values at 2.36 min and 6.67 min, respectively. The developed method was found to be simple, precise and accurate and can be useful for the quality control of raw material as well as formulations containing these phytoconstituents.
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