Novel First-Order Derivative UV Spectrophotometric Method for the Determination of Acarbose in Solid Dosage Forms

Karajgi, Santosh; Gaviraj, E.N.; Mali, Sunayana

doi:10.25258/ijpqa.11.2.15

Cited by 3 publications

(2 citation statements)

References 3 publications

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“…Hausner's ratio The Hausner's ratio, determined by using Equation, is related to interparticle friction and can be used to predict the powder flow properties. (46)(47)(48)(49)(50) Hausner's ratio = TappedDensity Bulk Density…”

Section: Compressibility Indexmentioning

confidence: 99%

Review: Therapetic Approach in the Management of Osteoarthritis

Gawai,

Dhoble,

Padole

et al. 2023

Asian J Pharm Res Dev

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Objectives: The goal in designing sustained or controlled delivery systems is to reduce the frequency of dosing or to increase the effectiveness of the drug by localization at the site of action, reducing the dose required, and providing uniform drug delivery. A sustained release system is a type of modified drug delivery system that can be used as an alternative to a conventional drug delivery system. Summary: Osteoarthritis is a generative disease of synovial joints characterized by focal loss of articular hyaline cartilage with the proliferation of new bones and remodelling of joint contour. Risk factors of osteoarthritis are age, female gender, joint alignment, hereditary gene defect, joint injury and obesity.There are various symptoms of osteoarthritis and It diagnose by blood test, joint fluid test and MRI. Osteoarthritis is treated by self-care, medications, therapies, and surgeries. A sustained-release dosage form is a dosage form that maintains the therapeutic blood or tissue levels of the drug by continuous release of medication. Formulation of granules by wet granulation and the granules are evaluated by the pre-compression and post-compression studies. Conclusion: Sustained release tablet optimize drug release for extended time period.It maximized effectiveness, reduced side-effects of drug and cures the disease.

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Section: Compressibility Indexmentioning

confidence: 99%

Review: Therapetic Approach in the Management of Osteoarthritis

Gawai,

Dhoble,

Padole

et al. 2023

Asian J Pharm Res Dev

View full text Add to dashboard Cite

show abstract

“…Various analytical methods used for the determination of this drug in the body fluid and pharmaceutical preparations. These include Spectrofluorometric method 7, 8 , Gas Chromatography GC 9 , Sequential injection analysis 10 , High-Performance Method HPLC [11][12][13][14][15][16][17] , High-Performance Thin Layer Chromatography HTLC 18 , Capillary electrophoresis 19,20 , Voltammetry 21 and UV-spectro-photometric [21][22][23][24][25][26][27][28][29][30] . The current paper reports a simple, sensitive spectrophotometric method for determination of Etodolac via the reaction of the drug with ferric ion Fe 3+ to form the corresponding ferrous ion Fe 2+ and subsequent reaction with potassium hexacyanoferrate to form a colored compound that is absorbed in 700 nm.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2019

IJPSR

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In this study, we developed a cheap and precise analytic method to measure Etodolac concentration in bulk and pharmaceutical formula. The modified, updated method depends on the reaction between ferric ion and Etodolac to yield ferrous ion. Then the former ion reacted with potassium ferric cyanide to form colored compound has a maximum absorbance at 700 nm. The method was validated by calculating the precision and accuracy. The method follows Beer-Lamber law so that we used the range between 1-22.5 µg/mL and the correlation coefficient at 0.997. Accuracy and precision of the proposed method were estimated and shown average of recoveries between (96.67-99.0%) with precision represented by RSD % equal to 1.02. We also calculated the detection limit (LOD) and quantitative limit (LOQ), which respectively were 0.6 µg/mL and 1.2 µg/mL. The modified suggested method was used to measure Etodolac in pharmaceutical preparation without drug additives interference and shows a good agreement with the standard method. Therefore, it can be used for routine works for quality control for the estimation of the Etodolac in bulk and pharmaceutical preparation as tablets. FIG. 1: CHEMICAL STRUCTURE OF ETODOLACChemically, Etodolac is white crystals, waterinsoluble and soluble in organic solvents like alcohols, chloroforms, dimethylsulfoxide, and aqueous polyethylene glycols.

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Simultaneous Uv Method Development for Determination of Rotigotine Hydrochloride and Rasagiline Mesylate

Patel¹,

Jha²

2023

IND. DRU.

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A precise, accurate analytical UV spectroscopic method has been developed for simultaneous estimation of rotigotine hydrochloride and rasagiline mesylate by using first order derivative spectroscopy. 50 µg mL-1 solutions of both drugs were scanned in the range of 200-800 nm and the first order overlain spectra of both drugs to check zero crossing points. Rotigotine hydrochloride showed zero crossing point at 239 nm where and rasagiline mesylate showed at 273 nm. Six-point calibration curves shown linearity in 2-12 µg mL-1 concentration range for rotigotine hydrochloride and 10-60 µg mL-1 concentration range for rasagiline mesylate. Regression equation obtained for both drugs were used further for determination of concentration in accuracy studies and developed product. In bulk drugs, rasagiline mesylate showed recovery of 98.33-100.93 % and rotigotine hydrochloride showed recovery of 101-103 %. The results obtained from analysis were validated according to ICH guidelines and were found at up to the mark.

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Novel First-Order Derivative UV Spectrophotometric Method for the Determination of Acarbose in Solid Dosage Forms

Cited by 3 publications

References 3 publications

Review: Therapetic Approach in the Management of Osteoarthritis

Review: Therapetic Approach in the Management of Osteoarthritis

Untitled

Simultaneous Uv Method Development for Determination of Rotigotine Hydrochloride and Rasagiline Mesylate

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