Objective: The study aimed to determine the effect of rosemary (Rosmarinus officinalis L.) leaf extract on healing angular cheilitis induced byStaphylococcus aureus and Candida albicans in male Wistar rats.Methods: We assessed 24 male Wistar rats that were divided into four groups: The first group was induced by S. aureus and given rosemary leafextract, the second group was induced by S. aureus and given gentamicin, the third group was induced by C. albicans and given rosemary leaf extract,and the fourth group was induced by C. albicans and given miconazole. All rats in each group were treated, and wound length and erythema wereobserved for 7 days.Results: The average wound length on the 7th day was 0.00±0.0 mm in the first group, 0.29±0.4 mm in the second group, 0.00±0.0 mm in the thirdgroup, and 0.25±0.2 mm in the fourth group. Statistical analysis demonstrated significant differences in wound length for each treatment group.Conclusion: Rosemary leaf extract has a healing effect on angular cheilitis induced by S. aureus and C. albicans in male Wistar rats.
Cancer is a chronic disease and is the third leading cause of death in children aged 1-14 years. About one third of cancer in child-ren is leukemia with an incidence of 9 cases per 100,000 population. Leukemia is a malignancy of blood cells originating from the bone marrow and can occur in children and adults. Early detection of oral lesions is very important for the prevention and treatment of complications that may arise during therapy, a better prognosis, lower morbidity and mortality for that disease. Oral manifestations of leukemia are gingival enlargement and spontaneous bleeding, oral ulceration, petechiae, hematoma and pale mucosa. Oral lesions occur in both acute and chronic forms of all types of leukemia and are more common in the acute stage. Dental care for patients with leukemia should be focused on preventing injury, local control of gingival bleeding by re-moving the biofilm, and prevention of oral infection. Oral hygiene by brushing teeth, use of fluoride, and a non-cariogenic diet should also be emphasized during treatment.
Objective: to assess awareness of senior community in the Belawa distric, Wajo, South Sulawesi, Indonesia regarding their oral soft tissue abnormality specifically regard to Oral potentially malignant disorders, and to assess community ability to descript any pain or uncomfortably origin from their oral cavity. Methods: A self-made questionnaire written in Indonesia language was given to the old aged-adult based on WHO criteria with age range between 45 to 75 years old, who was willing to participate in this study. The questioner consists some picture representing oral mucosal cavity with clinical feature of some ulcers, clinical feature of candida infection, and some clinical appearances of oral potentially malignant disorders. Results: In term of oral mucosal diseases questions, 22 (55%) participants had history of ulceration, however only 5 (45%) participants could specifically point out its previous ulcer location. However, history of pain only stated by 11 (28%) participants, 24 (60%) did not experienced any pain, and 5 (12%) did not answer the questions. Conclusion: knowledge and awareness regarding oral health lesion, especially the associated-potentially malignant lesion was far from ideal in the Belawa Community.
Plants are often used as herbal medicines because their active substances have known. Mangrove as herbal medicines are still under-researched; mangrove leafextract can be useful as anti-inflammatory, antibiotic, hemolytic drug, hypoglycemic has been specifically investigated for its inhibitory power againstStaphylococcus aureus as one of the causes of angular cheilitis and shows good results. This true experimental laboratory research with a posttest only control group design used 24 male white rats of the Wistar strain which were divided into group-1 were induced with S.aureus and given mangrove leaf extract, thegroup-2 was induced with S.aureus and given gentamicin, the group-3 was induced with C.albicans and given mangrove leaf extract, and the group-4 was induced with C.albicans and given miconazole. On the third day, wound length in the first group-1 was 0.23±0.2, in the group-2 was 0.00±0.0, in the group-3was 0.21±0.2, and the group-4 was 0.16±0.2. Based on the Friedman test, it showed significant results (p<0.05). It was concluded that mangrove leaf extract accelerated the wound closure process of angular cheilitis induced by S.aureus and C.albicans.
Tuberkulosis (TB) adalah penyakit infeksi menular yang menyerang berbagai organ tubuh terutama paru-paru yang disebabkan bakteri Mycobacterium tuberculosis. Penderita TB dapat menunjukkan gambaran klinis oral walaupun sangat jarang. Salah satunya yaitu ulser, yaitu lesi yang berupa hilangnya lapisan epitel hingga dibawah jaringan mukosa. Penelitian ini dilakukan untuk mengetahui gambaran klinis ulser rongga mulut pada penderita TB dan keberadaan infeksi bakteri Mycobacterium tuberculosis terhadap ulser. Penelitian observasional analitik dengan desain cross-sectional study ini dilakukan melalui pemeriksaan rongga mulut pada 30 penderita TB untuk melihat adanya ulser dan gambaran klinisnya. Untuk melihat keberadaan Mycobacterium tuberculosis dengan kultur pada medium Lowenstein-Jensen serta pewarnaan Ziehl-Neelsen.Penelitian ini menunjukkan bahwa kejadian ulser pada penderita TB ditemukan pada satu orang dengan gambaran klinis ulser berupa lesi tunggal, terletak di gingiva bukal rahang atas, ireguler, batasnya jelas, dan tidak nyeri. Hasil kultur laboratorium menunjukkan bahwa tidak ditemukan infeksi dari Mycobacterium tuberculosis. Dalam penelitian ini diketahui bahwa angka kejadian ulser pada penderita TB yaitu 3,3% dan ulser TB bersifat non spesifik pada gambaran klinisnya. Kata kunci: tuberkulosis, ulser, Mycobacterium tuberculosis ABSTRACT
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