Early detection and manifestation of leukemia in the oral cavity of the child

Abstract

Cancer is a chronic disease and is the third leading cause of death in children aged 1-14 years. About one third of cancer in child-ren is leukemia with an incidence of 9 cases per 100,000 population. Leukemia is a malignancy of blood cells originating from the bone marrow and can occur in children and adults. Early detection of oral lesions is very important for the prevention and treatment of complications that may arise during therapy, a better prognosis, lower morbidity and mortality for that disease. Oral manifestations of leukemia are gingival enlargement and spontaneous bleeding, oral ulceration, petechiae, hematoma and pale mucosa. Oral lesions occur in both acute and chronic forms of all types of leukemia and are more common in the acute stage. Dental care for patients with leukemia should be focused on preventing injury, local control of gingival bleeding by re-moving the biofilm, and prevention of oral infection. Oral hygiene by brushing teeth, use of fluoride, and a non-cariogenic diet should also be emphasized during treatment.

Diagnosing an Acute Leukemia From a Necrotizing Ulcerative Gingivitis in The Oral Cavity: a Case Report

“…The patient's general symptoms include bleeding, weakness and fatigue, respiratory symptoms, and fever. 10 Clinical findings help in the differential diagnosis of NUG from other diseases such as primary herpetic gingivostomatitis, desquamative gingivitis, and chronic destructive periodontal disease. 5 The role of the dentist in identifying the oral manifestations of leukemia is very important where the diagnosis of leukemia is sometimes made after a dental examination.…”

Antioxidant Effect of Mouthwash Containing Zinc, Aloe Vera, and Stabilized Chlorine Dioxide for Oral Manifestation of Acute Myeloblastic Leukemia (Aml)

“…Acute Myeloblastic Leukemia (AML), which is a hematological malignancy commonly found in children, need an accurate and rapid diagnosis [1][2][3]. The etiology of AML is poorly defined.…”

“…The oral manifestation of AML is usually associated with bleeding due to pancytopenia [3,4]. Cheilitis with bleeding followed by severe hemorrhagic crust formations on the lips is one of the manifestations that can sometimes be found and become secondary lesions of the cracked lips [1,[9][10][11]. Meanwhile, the side effects of chemotherapy are common and become lifethreatening.…”