The aim of this study was to determine the correlation of corneal endothelial cell density, coefficient of variation and hexagonal cell ratio with the stages of keratoconus and corneal thickness. Material and Methods: The study included 102 eyes from 51 patients. The corneal topography was performed using the Sirius corneal topographic device and the examination of the endothelium was performed using Nidek CEM-530. The patients were divided into groups in accordance with keratometry values (group 1: K2<45 D, group 2: K2 45-52 D, group 3: K2> 52 D) and thinnest cornea thickness (group 1:> 450 µm, group 2: 400-450 µm, group 3: <400 µm). Specular microscopic findings were compared according to the severity of keratoconus and corneal thickness. Results: Of the patients, 29 (50%) were male and 22 (50%) were female. The mean age was 29.8 ± 7.7 (15-45) years. Endothelial cell count and hexagonal cell ratio were significantly lower in severe keratoconus compared to mild and moderate keratoconus and the coefficient of variation was higher in severe keratoconus compared to the other groups (p <0.001). When the patients were compared according to the pachymetry value at the thinnest point of the cornea, the endothelial cell number and the hexagonal cell ratio were found to be lower in the group with pachymetry less than 400 µm (p <0.001). The coefficient of variation was higher in the same group compared to the others (p <0.001). Conclusion: It was revealed that endothelial cell density, hexagonal cell ratio decreased and the coefficient of variation increased with the progression of keratoconus. Specular microscopic examinations in patients with keratoconus provide important data in addition to topography.
Orcid : Turgay Ucak https://orcid.org/ 0000-0002-4977-4942 Nurdan Gamze Tasli https://orcid.org/ 0000-0001-8587-3430 Erdinç Bozkurt https://orcid.org/ 0000-0002-5570-799X Erel Icel https://orcid.org/ 0000-0001-7150-5581 Yücel Karakurt https://orcid.org/ 0000-0001-8104-3819 Sümeyye Burcu Ağcayazı https://orcid.org/0000-0003-4673-9233 Mahmut Atum https://orcid.org/0000-0001-8230-8137 ARAŞTIRMA MAKALESİ / Research Article Öz Amaç Anizometropiye bağlı tek taraflı ambliyopisi bulunan olguların retina sinir lifi tabakası (RSLT), maküla kalınlığı (MK) ve gangliyon hücre kompleksinin (GHK) optik koherens tomografi (OKT) cihazı ile değerlendirilip, sonuçların sağlam göz ve kontrol grubuyla karşılaştırılması.. ( Sakarya Tıp Dergisi 2019, 9(3):420-425 ) Gereç ve YöntemlerÇalışmaya tek gözde anizometropik ambliyopi tespit edilen 89 hastanın 89 ambliyop gözü, kontrol grubu olarakta hasta grubunun 89 sağlam gözü ve 31 sağlıklı kişinin 62 gözü çalışmaya dahil edildi. Tüm olguların detaylı oftalmolojik muayenesinin ardından OKT cihazı ile RSLT, MK ve GHK değerleri ölçülerek istatistiksel olarak karşılaştırıldı, p<0,05 değeri istatistiksel olarak anlamlı kabul edildi.Bulgular Çalışmaya dahil edilen katılımcıların yaş ortalamaları ambliyopi hasta grubunda 13.19±6.28 yıl, kontrol grubunda ise 13.50±6.50 yıl idi. MK analizlerine bakıldığında gruplar arasında anlamlı farklılık tespit edilmedi. Olguların ortalama RSLT değerleri arasında gruplar istatistiksel olarak anlamlı farklılık saptanamamışken; superior ve inferior kadran kalınlığı ambliyop gözlerde kontrol grubuna göre anlamlı olarak yüksek bulundu (sırasıyla; p=0,045, p=0,026). GHK değerlendirmesinde üst kadran kontrol grubunda hasta grubuna göre anlamlı olarak daha inceydi (p=0,026).Sonuç MK değerinde ambliyopi olguları ile kontrol grubu arasında anlamlı fark bulunmazken, RSLT' de üst ve alt kadran ile GHK üst kadran kalınlıkları hasta grubunda kontrol grubuna göre istatiksel olarak anlamlı yüksek bulunmuştur.Anahtar Kelimeler ambliyopi; optik koherens tomografi; retina sinir lifi tabakası; gangliyon hücre kompleksi Med J 2019, 9(3):420-425 ). Abstract Objective To determine nerve fiber layer (RNFL), macular thickness (MT) and ganglion cell complex (GCC) in eyes of children with anisometropic amblyopia, their fellow eyes and eyes of age-matched controls.( Sakarya Materials and MethodsIn this study, 89 eyes of 89 patients with amblyopia, 89 eyes without amblyopia, and 62 eyes of 31 normal subjects were included. After detailed ophthalmological examination, RNFL, MT and GCC measurements were performed with OCT and compared among the three groups, p<0,05 was taken to be significant. ResultsThe mean age of the participants was 13.19 ± 6.28 years in amblyopia patients; the control group was 13.50 ± 6.50 years. MT analysis showed no significant difference between the groups. The mean RNFL was evaluated for all three groups, no statistically significant difference was found. Superior and inferior quadrant thickness were significantly higher in amblyopic eyes than the control group (r...
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