Protection against experimental cisplatin-induced optic nerve toxicity using resveratrol: A rat model study

Ağcayazi, Sümeyye Burcu; Uğurlu, Adem; Uçak, Turgay; Taşlı, Nurdan Gamze; Karakurt, Yücel; İçel, Erel; Çimen, Ferda Keskin; Süleyman, Halis

doi:10.1080/15569527.2021.1940195

Cited by 3 publications

(2 citation statements)

References 38 publications

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“…Finally, the lesions were scored as 0–10%: no lesions; 10–25%: mild; 25–50%: mild-moderate; 50–75%: moderate-severe; and 75–100%: marked-critical. 17…”

Section: Methodsmentioning

confidence: 99%

Azilsartan suppresses the antiapoptotic biomarker and pro-inflammatory cytokines in rat model of cisplatin-induced retinal and optic nerve toxicity

Raheem

Mahmood

2023

Hum Exp Toxicol

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Background The local renin-angiotensin system has been discovered in the eyes; thus, this study evaluates the Azilsartan effect in the retina and optic nerve toxicity induced by Cisplatin in vivo. Methodology Forty-eight male rats were randomly assigned into six groups of 8 animals. Group 1 was healthy control that received 0.5 mL/day of 0.5% carboxymethyl cellulose (CMC) orally (PO). Group 2 received a single dose of the 7.0 mg/kg CIS intraperitoneally with 0.5 mL/day of 0.5% CMC-PO. Groups 3 and 4 received 3.5 and 7.0 mg/kg/day of AZIL-PO, respectively. Groups 5 and 6 received 3.5 and 7.0 mg/kg/day of AZIL-PO, respectively together with a single dose of 7.0 mg/kg of CIS-IP. The ocular tissue and serum estimated the TNF-α, NF-kβ, and Casp-3. A complete blood count was also measured, and the eye was sent for histological examination. Results The administration of the 3.5 mg/kg AZIL significantly ( p < 0.05) reduced the ocular tissue and serum TNF-α, NF-kB, and Casp-3 levels, when given to CIS treated group, while the 7.0 mg/kg AZIL does not. Additionally, azilsartan shows no negative impact on the CBC in rats. Finally, the eye histological examination showed a significant ( p < 0.05) drop in the signs of inflammation and cellular degeneration, particularly after administration of the 3.5 mg/kg AZIL to the CIS-treated group. Conclusion A low dose of AZIL exerts an anti-inflammation and an anti-apoptotic effect through significant suppression of the pro-inflammatory mediators and an apoptotic biomarker by blocking the local angiotensin II type

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“…Finally, the lesions were scored as 0–10%: no lesions; 10–25%: mild; 25–50%: mild-moderate; 50–75%: moderate-severe; and 75–100%: marked-critical. 17…”

Section: Methodsmentioning

confidence: 99%

Azilsartan suppresses the antiapoptotic biomarker and pro-inflammatory cytokines in rat model of cisplatin-induced retinal and optic nerve toxicity

Raheem

Mahmood

2023

Hum Exp Toxicol

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“…Cisplatin causes an increase in the production of reactive oxygen species and depletion of the intrinsic antioxidant system, which results in cell membrane lipid peroxidation, activation of the p38 Mitogen-activated protein kinases (MAPKs) signaling pathway, and dysfunction of the DNA repair mechanism (7) . Accordingly, several studies were conducted to overcome Cisplatin ocular toxicity by using antioxidants such as selenium and resveratrol to minimize the oxidative stress and protect the eye from the toxic effects of Cisplatin ( 8,9) . The positive involvement of the angiotensin receptor blockers (ARBs) in ameliorating the diseases that are associated with the eye has been studied due to the local availability of angiotensin II type 1 (AT1) receptors in the ocular tissues (10,11 ).…”

Section: ‫التحسن‬ ‫التأثير‬ ‫ي‬ ‫الجرذان‬ ‫ذكور‬ ‫في‬ ‫بالسيسبالتين‬ ...mentioning

confidence: 99%

Ameliorating Effect of Azilsartan on Cisplatin -Induced Ocular Toxicity in Male Rats

Mahmood,

Noor Majid Raheem Kareem1

2023

IJPS

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Objective: To evaluate the protective effect of Azilsartan against Cisplatin-induced ocular damage by ameliorating the oxidative stress and inflammation status, as well as to compare two different doses of Azilsartan to the Resveratrol. Fifty-six male Wister albino-rats, weighing 270±30 g. The rats were allocated at random into seven groups (n=8 per group), as follows: Group 1 (Healthy control) was given 0.5% CMC orally for the 14 days. Group 2 (Positive control) was given a single injection of 7mg/kg Cisplatin intraperitoneally and then 0.5% CMC orally for the following 14 days. Group 3 was given 3.5mg/kg Azilsartan orally for the following 14 days. Group 4 was given 7mg/kg Azilsartan orally for the following 14 days. Group 5 was given a single injection of 7mg/kg Cisplatin intraperitoneally and then 3.5mg/kg Azilsartan orally for the following 14 days. Group 6 was given a single injection of 7mg/kg Cisplatin intraperitoneally and then 7mg/kg Azilsartan orally for the following 14 days. Group 7 (standard) was given 25mg/kg/day Resveratrol orally for following 14 days.Azilsartan at low dose (3.5mg/kg) showed a significant reduction in IL-1β pro-inflammatory marker level, whereas there was no significant effect on MDA and SOD levels in cisplatin-induced ocular damage. Histologically, there were significant reduction in inflammatory exudates, edema, and inflammatory cells infiltration with both doses. Additionally, there were no significant difference among Azilsartan only received groups and Resveratrol group. Azilsartan shows a promising anti-inflammatory effect in ocular tissue in Cisplatin experimental rat models by significantly reducing IL-1β overexpression, through its potent AT1receptor blocking effect. However, Azilsartan showed a slight effect on MDA levels and marginal effect on SOD levels in Cisplatin-induced ocular toxicity. Furthermore, Azilsartan at a low dose slightly mimicked the effect of resveratrol on normal ocular tissue, suggesting an advancement in prophylactic application in ocular injury. Keywords: Azilsartan, IL-1β, Cisplatin, Ocular Toxicity

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Evaluation of histologic, antiapoptotic and antioxidant effects of melatonin against the acute ocular toxicity of Cisplatin

Polat,

Karabulut,

Akkul

et al. 2023

Tissue and Cell

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Protection against experimental cisplatin-induced optic nerve toxicity using resveratrol: A rat model study

Cited by 3 publications

References 38 publications

Azilsartan suppresses the antiapoptotic biomarker and pro-inflammatory cytokines in rat model of cisplatin-induced retinal and optic nerve toxicity

Azilsartan suppresses the antiapoptotic biomarker and pro-inflammatory cytokines in rat model of cisplatin-induced retinal and optic nerve toxicity

Ameliorating Effect of Azilsartan on Cisplatin -Induced Ocular Toxicity in Male Rats

Evaluation of histologic, antiapoptotic and antioxidant effects of melatonin against the acute ocular toxicity of Cisplatin

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