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This research included the detection and determination of flavonoids from Centaurea Cineraria extract collected from public gardens using high-performance liquid chromatography technique. The compounds (Cirsilineol, Jaceosidin, Melitensin) were found, their concentrations were measured and found (36254,63719,89035 µg/ml), and qualitative chemical detections were performed. Study of the effect of the methanolic extract of Centaurea Cineraria containing the flavonoids mentioned above. The extraction process was carried out using an ordinary organic solvent ethanol and using a rotary evaporator device. The flavonoids present in the extract were detected, using standard flavonoids (Cirsilineol, Jaceosidin, Melitensin) and study the effect of the extacts on some cancer cell line also study on utilizing stable free extreme compound 1, 1-Diphenyl-2-Picryl-hydrazil (DPPH). Results uncovered that the more expanding in centralization of the concentrate the seriously rummaging level of the free extremists. The fixations that were utilized gone from36.12 to 2000µg/ml, considered the Methanol concentrate of Centaurea Cineraria essentially showed high anticancer activity agent movement (96% at 2000µg/ml) connected with hexane extricates which were 94.61% at 2000µg/ml. This work additionally planned to concentrate on the cytotoxic and anticancer impacts of Centaurea Cineraria extricates The predominant decrease in attainable count cell was 500/ml in various cell lines, which was associated to methanolic isolates and appeared to cause cell loss in the cell lines L20B, PC-3, and HCT116 separately.
Background: Prosopis fracta is a valuable and useful medicinal plant for the purpose of extracting flavonoids and it is one of the most important plants with medicinal properties. Prosopis fracta is found in many southern regions of Iran.
Objective: the aim of this review Phytochemistry and biological activity of Prosopis fracta.
Material and Methods: Initially, the powder was degreased by hexane and then after completion of the extraction process, we obtained a rotary solvent removal and the rest of the extract was frozen for retention, then it stored at -23°C. The freeze-dried samples are dissolved in methanol and permanently filtered through a 0.35 syringe filter.
Results: Prosopis fracta extracts using to treat cancer, which destroying activity via mitochondrial changes, as showed a good example for increased reactive oxygen species (ROS) levels, SIRT3 activity and cell death in HT-29 related to the intestines and rectum cancer cells.
Conclusion: Antimicrobial and phytochemical studies provide valuable insight into understanding media. Sometimes the idea of the route responsible for the activity of these phytochemicals against oxidizing compounds that act as a source of harmful chemical to the body is removal from service of protein and loss of function.
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