Primary hepatic neoplasms are usually composed of hepatocytes, biliary epithelial cells, endothelial cells, or a combination of these with various mesenchymal cells, and typically arise in older animals (Chege et al, 2015).The primary hepatic neoplasms are generally classified as cholangiocarcinoma (CC), hepatocellular adenoma, and hepatocellular carcinoma (HCC) (Goodman, 2007).The CC is a primary adenocarcinoma arising from biliary tracts and considered as the second most frequent primary hepatic neoplasm. The hepatocellular adenoma, a benign tumor, is uncommon but appears solid, and presumable epithelial origin that usually develops in a healthy liver. Meanwhile, the HCC is the most frequent form of primary hepatic neoplasm (Goodman, 2007). It is commonly composed of tumor cells that resemble hepatocytes, and consists of a single variable mass that develops and replaces the parenchyma (Chege et al, 2015). The histological diagnosis of the HCC poses many challenges particularly due to its heterogeneity, and the difficulty to confirm a differential diagnosis in some instances (Quaglia, 2018).Hepatic neoplasms have been frequently reported in captive wild animals, including Polar bear (Ursus maritimus), Malayan sun bear (U. malayanus), Sloth bear (U. ursinus), Eurasian badger (Meles meles), and antelopes,
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