No abstract

In this work, a simple and reliable method for the synthesis of β-cyclodextrin (β-CD)-grafted silica nanoparticles (SiNPs) is developed. The synthetic protocol included postsynthesis functionalization of silica nanoparticles with aminopropyl trimethoxysilane (APTES) followed by the condensation of the amino groups with imidazole carbamate ester of β-CD. The activated β-CD (carbamate ester) was prepared by reacting it with carbonyldiimidazole (CDI). The grafting of (β-CD) on SiNPs was confirmed by ATIR-IR, DLS, and TGA analyses. The method developed can be easily reproduced with any other oxide nanoparticles for the preparation of β-CD-grafted nanoparticles.