Green and sustainable synthesis of silica nanoparticles

Karande, Sudip D.; Jadhav, Sushilkumar A.; Garud, Harshada B.; Kalantre, Vilas A.; Burungale, Shivaji H.; Patil, Pramod S.

doi:10.1007/s41204-021-00124-1

Cited by 63 publications

(20 citation statements)

References 78 publications

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“…Various researchers used green synthesis route to obtain amorphous silica nanoparticles (SNPs) using rice husk and sugar beet bagasse [22]. The researchers who used rice husk successfully obtained semi-crystalline porous silica nanoparticles and silica nanoparticles [29,61]. On the other hand, the researchers who used sugar beet bagasse also synthesized silica nanoparticles [62].…”

Section: Synthesis Of Snps (Biogenic Methods)mentioning

confidence: 99%

“…In this respect, the nanotechnological developments are showing to be a supportive and contributive factor in medical research [100]. Nanotechnology has already shown promising results in drug delivery, diagnosis, medical imaging, cancer treatment, diabetes treatment and more [19,61,79]. SNPs have shown to be good adsorption and immobilization medium for quinizarin diester [101].…”

Section: Biomedical and Biotechnological Applications Of Snpsmentioning

confidence: 99%

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A Comprehensive Review of Synthesis, Applications and Future Prospects for Silica Nanoparticles (SNPs)

Akhter

Rao

Abbasi

et al. 2022

Silicon

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Silica nanoparticles (SNPs) have shown great applicability potential in a number of fields like chemical, biomedical, biotechnology, agriculture, environmental remediation and even wastewater purification. With remarkably instinctive properties like mesoporous structure, high surface area, tunable pore size/diameter, biocompatibility, modifiability and polymeric hybridizability, the SNPs are growing in their applicable potential even further. These particles are shown to be non-toxic in nature, hence safe to be used in biomedical research. Moreover, the molecular mobilizability onto the internal and external surface of the particles makes them excellent carriers for biotic and non-biotic compounds. In this respect, the present study comprehensively reviews the most important and recent applications of SNPs in a number of fields along with synthetic approaches. Moreover, despite versatile contributions, the applicable potential of SNPs is still a tip of the iceberg waiting to be exploited more, hence, the last section of the review presents the future prospects containing only few of the many gaps/research extensions regarding SNPs that need to be addressed in future work.

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Section: Synthesis Of Snps (Biogenic Methods)mentioning

confidence: 99%

Section: Biomedical and Biotechnological Applications Of Snpsmentioning

confidence: 99%

A Comprehensive Review of Synthesis, Applications and Future Prospects for Silica Nanoparticles (SNPs)

Akhter

Rao

Abbasi

et al. 2022

Silicon

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“…We used Laurus nobilis , a native plant from the Mediterranean area, containing several clusters of phytochemicals [ 50 ]. These molecules are directly involved as reducing agents for the eco-friendly synthesis of SiO 2 NPs [ 51 ], making the process cheap, time-saving, and sustainable [ 52 ]. This is in contrast with the microemulsion approach, characterized by expensive processes and numerous washing steps carried out to remove the toxic surfactants, as well as carcinogen solvents present in the synthetic mix [ 53 ].…”

Section: Resultsmentioning

confidence: 99%

High Doses of Silica Nanoparticles Obtained by Microemulsion and Green Routes Compromise Human Alveolar Cells Morphology and Stiffness Differently

Matteis

Cascione

Luca

et al. 2022

Bioinorganic Chemistry and Applications

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Among all the inorganic nanomaterials used in commercial products, industry, and medicine, the amorphous silica nanoparticles (SiO2 NPs) appeared to be often tolerated in living organisms. However, despite several toxicity studies, some concerns about the exposure to high doses of SiO2 NPs with different sizes were raised. Then, we used the microemulsion method to obtain stable SiO2 NPs having different sizes (110 nm, 50 nm, and 25 nm). In addition, a new one-pot green synthetic route using leaves extract of Laurus nobilis was performed, obtaining monodispersed ultrasmall SiO2 NPs without the use of dangerous chemicals. The NPs achieved by microemulsion were further functionalized with amino groups making the NPs surface positively charged. Then, high doses of SiO2 NPs (1 mg/mL and 3 mg/mL) achieved from the two routes, having different sizes and surface charges, were used to assess their impact on human alveolar cells (A549), being the best cell model mimicking the inhalation route. Cell viability and caspase-3 induction were analyzed as well as the cellular uptake, obtaining that the smallest (25 nm) and positive-charged NPs were more able to induce cytotoxicity, reaching values of about 60% of cell death. Surprisingly, cells incubated with green SiO2 NPs did not show strong toxicity, and 70% of them remained vital. This result was unusual for ultrasmall nanoobjects, generally highly toxic. The actin reorganization, nuclear morphology alteration, and cell membrane elasticity analyses confirmed the trend achieved from the biological assays. The obtained data demonstrate that the increase in cellular softness, i.e., the decrease in Young’s modulus, could be associated with the smaller and positive NPs, recording values of about 3 kPa. On the contrary, green NPs triggered a slight decrease of stiffness values (c.a. 6 kPa) compared to the untreated cells (c.a. 8 kPa). As the softer cells were implicated in cancer progression and metastasization, this evidence strongly supported the idea of a link between the cell elasticity and physicochemical properties of NPs that, in turn, influenced the interaction with the cell membrane. Thus, the green SiO2 NPs compromised cells to a lesser extent than the other SiO2 NPs types. In this scenario, the elasticity evaluation could be an interesting tool to understand the toxicity of NPs with the aim of predicting some pathological phenomena associated with their exposure.

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“…Among NPs, silica nanoparticles (SiNPs) are one of the top five nanomaterials involved in nanotech-based consumer products ( Park et al, 2011 ). Currently, silica nanoparticles (SiNPs) are widely used in different fields in food additives, drug delivery, medicine, and disease treatments ( Selvarajan et al, 2020 ; Purcar et al, 2021 ) because of their unique characteristics such as remarkable biocompatibility, stability, large surface area, and surface reactivity ( Gubala et al, 2020 ; Karande et al, 2021 ). The broad usage increases the human and animal exposure to different types of nanoparticles inducing toxicity ( Bahadar et al, 2016 ; Mahboub H. H. et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Silica Nanoparticle Acute Toxicity on Male Rattus norvegicus Domestica: Ethological Behavior, Hematological Disorders, Biochemical Analyses, Hepato-Renal Function, and Antioxidant-Immune Response

Almanaa

Aref

Kakakhel

et al. 2022

Front. Bioeng. Biotechnol.

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With extensive production and various applications of silica nanoparticles (SiNPs), there is a controversy regarding the ecotoxicological impacts of SiNPs. Therefore, the current study was aimed to assess the acute toxicity of silica nanoparticles in male Rattus norvegicus domestica after 24 and 96 h. Hematological, serum biochemical, stress biomarker, and immune-antioxidant parameters were addressed. Chemical composition, crystal structure, and the particle shape and morphology of SiNPs were investigated using XRD, FTIR, BET, UV-Vis, and SEM, while TEM was used to estimate the average size distribution of particles. For the exposure experiment, 48 male rats were divided into four groups (12 rat/group) and gavaged daily with different levels of zero (control), 5, 10, and 20 mg of SiNPs corresponding to zero, 31.25, 62.5, and 125 mg per kg of body weight. Sampling was carried out after 24 and 96 h. Relative to the control group, the exposure to SiNPs induced clear behavioral changes such as inactivity, lethargy, aggressiveness, and screaming. In a dose-dependent manner, the behavior scores recorded the highest values. Pairwise comparisons with the control demonstrated a significant (p < 0.05) decrease in hematological and immunological biomarkers [lysozymes and alternative complement activity (ACH50)] with a concomitant reduction in the antioxidant enzymes [catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD)] in all exposed groups to SiNPs. On the contrary, there was a noticeable increase in biochemical parameters (glucose, cortisol, creatinine, urea, low-density lipoproteins (LDL), high-density lipoproteins (HDL), total protein, and albumin) and hepato-renal indicators, including alkaline phosphatase (ALP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST), of all SiNP-exposed groups. It was observed that SiNPs induced acute toxicity, either after 24 h or 96 h, post-exposure of rats to SiNPs evidenced by ethological changes, hepato-renal dysfunction, hyperlipemia, and severe suppression in hematological, protein, stress, and immune-antioxidant biomarkers reflecting an impaired physiological status. The obtained outcomes create a foundation for future research to consider the acute toxicity of nanoparticles to preserve human health and sustain the environment.

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Green and sustainable synthesis of silica nanoparticles

Cited by 63 publications

References 78 publications

A Comprehensive Review of Synthesis, Applications and Future Prospects for Silica Nanoparticles (SNPs)

A Comprehensive Review of Synthesis, Applications and Future Prospects for Silica Nanoparticles (SNPs)

High Doses of Silica Nanoparticles Obtained by Microemulsion and Green Routes Compromise Human Alveolar Cells Morphology and Stiffness Differently

Silica Nanoparticle Acute Toxicity on Male Rattus norvegicus Domestica: Ethological Behavior, Hematological Disorders, Biochemical Analyses, Hepato-Renal Function, and Antioxidant-Immune Response

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