No abstract

Introduction: Gallstone disease is a major health problem and a significant health issue worldwide. This research was carried out to study the varied histopathological changes, demographic correlation and association of gall bladder pathologies to cholelithiasis on 114 cholecystectomy specimens. Materials and Methods: The present research was conducted at Department of Pathology, Prakash institute of medical sciences and research over a period of 3.5 years, July 2016 to December 2019. The gross examination was done after fixing the specimens in 10% formalin. Bits were given from fundus body and neck. Microscopic findings of the H&E-stained sections were noted. Results: 46.5% of the samples were present in the age range of 50-70 years with high female preponderance. On Microscopic examination, chronic inflammation was found in 69.2% of the cases. Cholelithiasis was seen in 67.5% of the specimens. Acute, acute on chronic, eosinophilic, gangrenous, xanthogranulomatous cholecystitis and a single case of adenomyomatosis were also seen. Conclusion:Gallstones produce a wide range of histopathological changes in mucosa which requires detailed histopathological analysis. The increasing rate of cholelithiasis calls for further research to signify its importance in diagnosis, demographic and future trends.

Introduction: Renal biopsy is the corner stone of diagnostics modalities in renal parenchymal disease and offers vital prognostic information for nephrologists. The present study was undertaken with a view to become familiar with the histological patterns of different renal lesions and their correlation with clinical manifestations, hematological and biochemical changes. Methods: This study includes 129 renal biopsies received in the Department of Pathology, Prakash institute of medical sciences and research over a period 3 years January 2017 to December 2019. In all the cases, percutaneous renal biopsy was done under local anesthesia. The technique used was that of Kark and Muehrcke via Wilms Silverman needle with Franklin's modification. Results: The commonest lesion observed was minimal change disease (31.87%). This was followed by acute glomerulonephritis (26.36%). Maximum number of cases were observed in second and third decade of life, together comprising about 70% of cases. Overall male preponderance was observed. The commonest cause of nephrotic syndrome was observed to be minimal change disease. Conclusion: Nephrotic syndrome is common in adults also as against the general belief. Minimal change disease and acute glomerulonephritis are the commonly observed lesions causing nephrotic syndrome in most of the cases.

No abstract

Introduction:The World health statistics 2012 report highlight on the growing problem of the noncommunicable diseases burden due to urbanisation and change in the life styles. According to the WHO report, one in three adults worldwide, has hypertension a condition that causes around half of all deaths from stroke and heart disease.In this study, we are using the common modifiable risk factors like obesity and exercise status to evaluate risk of hypertension in later life. So the present study is planned to calculate the risk score for the development of hypertension. Material & Method: It was a cross sectional study. Study was conducted on about 521 individuals between the age group of 18-50 yrs in Pune urban population. Risk factors like obesity,physical activity .family history and depression were used to assess score Results: In our study total 521 participants were included out of which 27%,58% and 15 % have mild, moderate and high risk of developing hypertension respectively in future. Conclusion: The study concludes that majority of urban Pune population have moderate risk of hypertension. This highlights need of preventable measures like counselling sessions, regular follow up, life style modification in form of increased physical activity and healthy diet.