A clinico-pathological study of percutaneous renal biopsies in South-western region of Maharashtra

Abstract

Introduction: Renal biopsy is the corner stone of diagnostics modalities in renal parenchymal disease and offers vital prognostic information for nephrologists. The present study was undertaken with a view to become familiar with the histological patterns of different renal lesions and their correlation with clinical manifestations, hematological and biochemical changes. Methods: This study includes 129 renal biopsies received in the Department of Pathology, Prakash institute of medical sciences and research over a period 3 years January 2017 to December 2019. In all the cases, percutaneous renal biopsy was done under local anesthesia. The technique used was that of Kark and Muehrcke via Wilms Silverman needle with Franklin's modification. Results: The commonest lesion observed was minimal change disease (31.87%). This was followed by acute glomerulonephritis (26.36%). Maximum number of cases were observed in second and third decade of life, together comprising about 70% of cases. Overall male preponderance was observed. The commonest cause of nephrotic syndrome was observed to be minimal change disease. Conclusion: Nephrotic syndrome is common in adults also as against the general belief. Minimal change disease and acute glomerulonephritis are the commonly observed lesions causing nephrotic syndrome in most of the cases.