The aim of the article is to present a rare case of Hairy cell leukaemia variant (HCl-V) which is a distinct clinico-pathological entity with intermediate features between classical HCl (HCl-C) and B-cell prolymphocytic leukaemia. It is an uncommon disorder accounting for approximately 0.4% of chronic lymphoid malignancies and 10% of all HCl cases. A 58 year old woman presented with pain abdomen and loss of weight. On examination she had massive splenomegaly. Peripheral smear was reported as chronic lymphoproliferative disorder (? Hairy cell leukemia or splenic lymphoma with villous lymphocytes). On Bone marrow examination, differential diagnosis was given as splenic lymphoma with villous lymphocytes (SLVL) and prolymphocytic variant of Hairy cell leukemia. On flow cytometric analysis, these cells were positive for CD11c, CD19, CD20, and CD22. Based on the clinical, peripheral smear, bone marrow and flow cytometry findings, a diagnosis of hairy cell leukaemia variant was confirmed. The differential diagnosis should always include SLVL, HCL-C and Japanese variant HCL because they have different clinical and biological features, particularly regarding their response to purine analogue-based treatment or splenectomy.

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Introduction: Gallstone disease is a major health problem and a significant health issue worldwide. This research was carried out to study the varied histopathological changes, demographic correlation and association of gall bladder pathologies to cholelithiasis on 114 cholecystectomy specimens. Materials and Methods: The present research was conducted at Department of Pathology, Prakash institute of medical sciences and research over a period of 3.5 years, July 2016 to December 2019. The gross examination was done after fixing the specimens in 10% formalin. Bits were given from fundus body and neck. Microscopic findings of the H&E-stained sections were noted. Results: 46.5% of the samples were present in the age range of 50-70 years with high female preponderance. On Microscopic examination, chronic inflammation was found in 69.2% of the cases. Cholelithiasis was seen in 67.5% of the specimens. Acute, acute on chronic, eosinophilic, gangrenous, xanthogranulomatous cholecystitis and a single case of adenomyomatosis were also seen. Conclusion:Gallstones produce a wide range of histopathological changes in mucosa which requires detailed histopathological analysis. The increasing rate of cholelithiasis calls for further research to signify its importance in diagnosis, demographic and future trends.