The importance of the fourth and higher order terms in the Taylor series expansion of the energy of the isospin asymmetric nuclear matter in the study of the neutron star crust-core phase transition is investigated using the finite range simple effective interaction. Analytic expressions for the evaluation of the second and fourth order derivative terms in the Taylor series expansion for any general finite range interaction of Yukawa, exponential or Gaussian form have been obtained. The effect of the nuclear matter incompressibility, symmetry energy and slope parameters on the predictions for the crust-core transition density is examined. The crustal moment of inertia is calculated and the prediction for the radius of the Vela pulsar is analyzed using different equations of state.

Abstract. Deformed and spherical even-even nuclei are studied using a finite range simple effective interaction within the Hartree-Fock-Bogoliubov mean field approach. Different parameter sets of the interaction, corresponding to different incompressibility, are constructed by varying the exponent γ of the density in the traditional densitydependent term. Ten of the twelve parameters of these interactions are determined from properties of asymmetric nuclear matter and spin polarized pure neutron matter. The two remaining parameters are fitted to reproduce the experimental binding energies known in 620 even-even nuclei using several variants of the rotational energy correction. The rms deviations for the binding energy depend on the value of γ and the way the rotational energy correction is treated but they can be as low as 1.56 MeV, a value competitive with other renowned effective interactions of Skyrme and Gogny type. Charge radii are compared to the experimental values of 313 even-even nuclei and the rms deviation is again comparable and even superior to the one of popular Skyrme and Gogny forces. Emphasis is given to the deformation properties predicted with these interactions by analyzing the Potential Energy Surfaces for several well deformed nuclei and the fission barriers of some nuclei. Comparison of the results with the experimental information, where available, as well as with the results of the Gogny D1S force shows satisfactory agreement.

Cardiovascular diseases (CVDs) are a group of conditions associated with heart and blood vessels and are considered the leading cause of death globally. Coronary heart disease, atherosclerosis, myocardial infarction represents the CVDs. Since CVDs are associated with a series of pathophysiological conditions with an alarming mortality and morbidity rate, early diagnosis and appropriate therapeutic approaches are critical for saving patients’ lives. Conventionally, diagnostic tools are employed to detect disease conditions, whereas therapeutic drug candidates are administered to mitigate diseases. However, the advent of nanotechnological platforms has revolutionized the current understanding of pathophysiology and therapeutic measures. The concept of combinatorial therapy using both diagnosis and therapeutics through a single platform is known as theranostics. Nano-based theranostics are widely used in cancer detection and treatment, as evident from pre-clinical and clinical studies. Nanotheranostics have gained considerable attention for the efficient management of CVDs. The differential physicochemical properties of engineered nanoparticles have been exploited for early diagnosis and therapy of atherosclerosis, myocardial infarction and aneurysms. Herein, we provided the information on the evolution of nano-based theranostics to detect and treat CVDs such as atherosclerosis, myocardial infarction, and angiogenesis. The review also aims to provide novel avenues on how nanotherapeutics’ trending concept could transform our conventional diagnostic and therapeutic tools in the near future.

We obtain here a new relation for the reduced electric quadrupole transition probability B(E2)↑ of a given nucleus in terms of its derivatives with respect to neutron and proton numbers based on a similar local energy relation in the Infinite Nuclear Matter (INM) model of atomic nuclei, which is essentially built on the foundation of the Hugenholtz-Van Hove (HVH) theorem of many-body theory. Obviously, such a relation in the form of a differential equation is expected to be more powerful than the usual algebraic difference equations. Although the relation for B(E2)↑ has been perceived simply on the basis of a corresponding differential equation for the local energy in the INM model, its theoretical foundation otherwise has been clearly demonstrated. We further exploit the differential equation in using the very definitions of the derivatives to obtain two different recursion relations for B(E2)↑, connecting in each case three neighboring even-even nuclei from lower to higher mass numbers and vice versa. We demonstrate their numerical validity using available data throughout the nuclear chart and also explore their possible utility in predicting B(E2)↑ values.Keywords: Reduced electric quadrupole transition probability; differential equation in the transition probability; recursion relations; neighboring even-even nuclei; local energy relation; infinite nuclear matter model.

From ancient times, plants and plant derived products are exploited as a prominent source of folkloric medicines with tremendous therapeutic potential for an array of health disorders. In the present study, ethanolic leaf extract of and were evaluated for free radical scavenging activity in model system. and showed tremendous DPPH free radical scavenging potential with an IC value of 184.88 and 305.39 µg/mL respectively at a concentration of 500 µg/mL. The ethanolic leaf extract of and also showed significant hydoxyl radical scavenging and total antioxidant activity. Ascorbic acid was used as positive control. The in vitro antioxidant activity was further supported by in vivo studies using radical scavenging mechanism in wild type and its isogenic deletion strains and . The mutant yeast cells substantially scavenged the stress generated by HO when supplemented with ethanolic leaf extract of and as evident from spot assays followed by fluorescence assay (DCF-DA) using fluorescence microscopic and intensity studies. and significantly neutralize the ROS level in yeast mutants with concomitant decrease in fluorescence intensity as compared to the untreated yeast cells. The results suggested the efficacy of and as potent antioxidants in yeast system and thus their futuristic applications in therapeutics.

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Biofilms are population of cells growing in a coordinated manner and exhibiting resistance towards hostile environments. The infections associated with biofilms are difficult to control owing to the chronicity of infections and the emergence of antibiotic resistance. Most microbial infections are contributed by polymicrobial or mixed species interactions, such as those observed in chronic wound infections, otitis media, dental caries, and cystic fibrosis. This review focuses on the polymicrobial interactions among bacterial-bacterial, bacterial-fungal, and fungal-fungal aggregations based on in vitro and in vivo models and different therapeutic interventions available for polymicrobial biofilms. Deciphering the mechanisms of polymicrobial interactions and microbial diversity in chronic infections is very helpful in anti-microbial research. Together, we have discussed the role of metagenomic approaches in studying polymicrobial biofilms. The outstanding progress made in polymicrobial research, especially the model systems and application of metagenomics for detecting, preventing, and controlling infections, are reviewed.

The characteristic physical properties of rotating neutron stars under the r-mode oscillation are evaluated using the finite-range simple effective interaction. Emphasis is given on examining the influence of the stiffness of both the symmetric and asymmetric parts of the nuclear equation of state on these properties. The amplitude of the r-mode at saturation is calculated using the data of particular neutron stars from the considerations of "spin equilibrium" and "thermal equilibrium". The upper limit of the r-mode saturation amplitude is found to lie in the range 10 −8 -10 −6 , in agreement with the predictions of earlier work.