Background. Lentigo maligna (LM) is a pigmented neoplasm on sun‐exposed skin of elderly patients. LM slowly increases in size and may become lentigo maligna melanoma (LMM), a potentially fatal malignancy. Complete excision is the treatment of choice. Mohs' micrographic surgery (MMS) with frozen and permanent sections may be used for complete eradication of the lesion, while sparing as much normal tissue as possible. The authors studied the efficacy of MMS for the treatment of LM and LMM.
Methods. Between 1985 and 1992, 45 patients with LM (26) and LMM (19) were treated with MMS. The authors' technique was to use examination of frozen sections and rush permanent sections (prepared and read within 24 hours). Positive frozen sections warranted further excision. For negative or equivocal frozen sections, surgery was interrupted until the examination of permanent sections was performed.
Results. All 45 patients were free of local disease and eyidence of metastases at an average of 29.2 months (range, 4–81 months) after therapy.
Conclusions. MMS aided by rush permanent sections yielded a prolonged disease free survival for all 45 patients with LM or LMM. Because the MMS technique minimizes the removal of normal tissue, and the local cure rate in this study was superior to that reported for conventional surgery, the authors recommend this technique for the treatment of LM and LMM. Cancer 1994; 73:2964–70.
A 57-year-old man presented with chest wall lesions and swelling of his left arm. The rapid onset of vesicular lesions in a dermatomal distribution resulted in an initial diagnosis of herpes zoster. Cutaneous biopsy revealed adenocarcinoma and further evaluation revealed a primary source of pulmonary adenocarcinoma. Lymphatic spread of tumor cells is the most likely source of the zosteriform skin lesions, but other possibilities are discussed.
This paper presents highlights from research conducted at the University of Liverpool to determine suitable fidelity criteria and guidelines for the modelling and simulation of the helicopter-ship dynamic interface environment. The paper begins by describing the characteristics of the helicopter-ship dynamic interface, explaining the motivation behind the research and reviewing the state-of-the-art in dynamic interface simulation. The development of a dynamic interface research environment based on an existing research simulator operated by the University of Liverpool is then described, before key results from a number of piloted simulation experiments are presented. These experiments were specifically designed to address fidelity sensitivity issues, such as, are unsteady airwake models necessary, or can a steady airwake model induce appropriate levels of pilot workload? What influence does the modelled ship geometry, or choice of atmospheric wind conditions have on the airwake model and on pilot workload? Finally, the paper concludes by briefly describing the relevance of these research findings to current and future industry programmes.
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