Cutaneous leukocytoclastic vasculitis. Serial histopathologic evaluation demonstrates the dynamic nature of the infiltrate

An immunohistopathologic study in cutaneous necrotizing vasculitis

“…Our results confirm the hypothesis of Zax et al, 11 who observed a temporal transition from a neutrophilic to a mononuclear infiltrate in an unique case of CNV. Other previous studies suggesting a dynamic behaviour of the inflammatory infiltrate in CNV were retrospective or were performed under experimental conditions.…”

An immunohistopathologic study in cutaneous necrotizing vasculitis

“…Our results confirm the hypothesis of Zax et al, 11 who observed a temporal transition from a neutrophilic to a mononuclear infiltrate in an unique case of CNV. Other previous studies suggesting a dynamic behaviour of the inflammatory infiltrate in CNV were retrospective or were performed under experimental conditions.…”

Prolonged urticaria with purpura: The spectrum of clinical and histopathologic features in a prospective series of 22 patients exhibiting the clinical features of urticarial vasculitis

“…It has been noted that in leukocytoclastic vasculitis, the infiltrate starts primarily as a neutrophilic one within the first 24 hours of appearance of the lesion, and is gradually replaced by a lymphocytic one when biopsied after 48 hours. 25 However, it has been shown in our cases Despite the small sample size and generally Asian/Oriental cohort, some clinical differences have emerged between the lymphocyte-predominant and neutrophil-predominant groups. The neutrophil-predominant group tends to fulfill all clinical criteria of prolonged urticaria, purpura, resolution with hyperpigmentation, and pain/tenderness compared with the lymphocyte-predominant group, which more often fulfills only 2 of the 3 minor criteria (P = .007).…”

Localization of hepatitis C virus in cutaneous vasculitic lesions in patients with type II cryoglobulinemia

“…Alternatively, the virus may be more resistant to tissue clearance mechanisms. This appears less likely because in the PLI lesion, which represents an older lesion (17), elimination of HCV, IgM, and IgG from the interstitium appeared equal. On the other hand, the findings of HCV without IgM and IgG in the PLI lesion in patient 5 most likely represents HCV alone trapped in the edematous vessel wall, because inflammatory infiltrate that may alter the detection of immunoglobulins was not present.…”

An immunohistopathologic study in cutaneous necrotizing vasculitis

“…Our results confirm the hypothesis of Zax et al, 11 who observed a temporal transition from a neutrophilic to a mononuclear infiltrate in an unique case of CNV. Other previous studies suggesting a dynamic behaviour of the inflammatory infiltrate in CNV were retrospective or were performed under experimental conditions.…”

Prolonged urticaria with purpura: The spectrum of clinical and histopathologic features in a prospective series of 22 patients exhibiting the clinical features of urticarial vasculitis

“…It has been noted that in leukocytoclastic vasculitis, the infiltrate starts primarily as a neutrophilic one within the first 24 hours of appearance of the lesion, and is gradually replaced by a lymphocytic one when biopsied after 48 hours. 25 However, it has been shown in our cases Despite the small sample size and generally Asian/Oriental cohort, some clinical differences have emerged between the lymphocyte-predominant and neutrophil-predominant groups. The neutrophil-predominant group tends to fulfill all clinical criteria of prolonged urticaria, purpura, resolution with hyperpigmentation, and pain/tenderness compared with the lymphocyte-predominant group, which more often fulfills only 2 of the 3 minor criteria (P = .007).…”

Localization of hepatitis C virus in cutaneous vasculitic lesions in patients with type II cryoglobulinemia

“…Alternatively, the virus may be more resistant to tissue clearance mechanisms. This appears less likely because in the PLI lesion, which represents an older lesion (17), elimination of HCV, IgM, and IgG from the interstitium appeared equal. On the other hand, the findings of HCV without IgM and IgG in the PLI lesion in patient 5 most likely represents HCV alone trapped in the edematous vessel wall, because inflammatory infiltrate that may alter the detection of immunoglobulins was not present.…”

An immunohistopathologic study in cutaneous necrotizing vasculitis

“…Our results confirm the hypothesis of Zax et al, 11 who observed a temporal transition from a neutrophilic to a mononuclear infiltrate in an unique case of CNV. Other previous studies suggesting a dynamic behaviour of the inflammatory infiltrate in CNV were retrospective or were performed under experimental conditions.…”

Prolonged urticaria with purpura: The spectrum of clinical and histopathologic features in a prospective series of 22 patients exhibiting the clinical features of urticarial vasculitis

“…It has been noted that in leukocytoclastic vasculitis, the infiltrate starts primarily as a neutrophilic one within the first 24 hours of appearance of the lesion, and is gradually replaced by a lymphocytic one when biopsied after 48 hours. 25 However, it has been shown in our cases Despite the small sample size and generally Asian/Oriental cohort, some clinical differences have emerged between the lymphocyte-predominant and neutrophil-predominant groups. The neutrophil-predominant group tends to fulfill all clinical criteria of prolonged urticaria, purpura, resolution with hyperpigmentation, and pain/tenderness compared with the lymphocyte-predominant group, which more often fulfills only 2 of the 3 minor criteria (P = .007).…”

Localization of hepatitis C virus in cutaneous vasculitic lesions in patients with type II cryoglobulinemia

“…Alternatively, the virus may be more resistant to tissue clearance mechanisms. This appears less likely because in the PLI lesion, which represents an older lesion (17), elimination of HCV, IgM, and IgG from the interstitium appeared equal. On the other hand, the findings of HCV without IgM and IgG in the PLI lesion in patient 5 most likely represents HCV alone trapped in the edematous vessel wall, because inflammatory infiltrate that may alter the detection of immunoglobulins was not present.…”