SUMMARYAim: To assess the efficacy of the 8-week therapy with esomeprazole 40 mg vs. pantoprazole 40 mg for healing erosive oesophagitis (EE) as part of a management study. Methods: Patients had a history of gastro-oesophageal reflux disease symptoms ( ‡6 months) and had suffered heartburn on at least 4 of the 7 days preceding enrolment. Endoscopies were performed to grade EE severity using the Los Angeles (LA) classification system at baseline, 4 and 8 weeks (if unhealed at 4 weeks). Heartburn severity was recorded by patients on diary cards. The primary end point was healing of EE by week 8 of treatment.Results: Of 3170 patients randomized, the intentto-treat population consisted of 3151 patients (63% male, mean age: 50.6 years, 27% Helicobacter pyloripositive). Esomeprazole 40 mg healed a significantly greater proportion of EE patients than pantoprazole 40 mg at both 4 weeks (life table estimates: esomeprazole 81%, pantoprazole 75%, P < 0.001) and 8 weeks (life table estimates: esomeprazole 96%, pantoprazole 92%, P < 0.001). The median time to reach sustained heartburn resolution was 6 days in patients receiving esomeprazole and 8 days with pantoprazole (P < 0.001). Conclusion: Esomeprazole 40 mg is more effective than pantoprazole 40 mg for healing EE and providing resolution of associated heartburn.

Privately owned public spaces are frequently criticized for diminishing the publicness of public space by restricting social interaction, constraining individual liberties, and excluding undesirable populations. This study empirically determines whether, as is commonly believed, privately owned public spaces are more controlled than publicly owned spaces. To frame our empirical work, we propose a conceptual model that identifies publicness as the interaction between the ownership, management, and uses/users of a space. We then examine the management dimension using an observation-based index to assess spatial management paradigms in publicly and privately owned spaces. We find that the use of the private sector to provide publicly accessible space leads to increased control over use, behavior, and access. Furthermore, while both publicly and privately owned public spaces tend equally to encourage public use and access, managers of privately owned spaces tend to employ more features that control behavior within those spaces. More specifically, spatial control in privately owned spaces is normally achieved through the use of surveillance and policing techniques as well as design measures that ‘code’ spaces as private. Important findings are presented for planners, policy makers, and others concerned with the future of publicly accessible spaces.

SUMMARYBackground: Following initial healing of erosive oesophagitis, most patients require maintenance therapy to prevent relapse. Aim: To compare endoscopic and symptomatic remission rates over 6 months' maintenance therapy with esomeprazole or pantoprazole (both 20 mg once daily) in patients with healed erosive oesophagitis. Methods: Patients with symptoms of gastro-oesophageal reflux disease and endoscopically confirmed erosive oesophagitis at baseline were randomized to receive esomeprazole 40 mg or pantoprazole 40 mg for up to 8 weeks. Patients with healed erosive oesophagitis and free of moderate/severe heartburn and acid regurgitation at 4 weeks or, if necessary, 8 weeks entered the 6-month maintenance therapy phase of the study.

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This paper compares the planning process in Germany and the United States. We note fundamental institutional and structural differences between the two countries and discuss recent trends and patterns. Contrary to the US, planning in Germany is mediated through a vertically integrated and consensus-oriented institutional framework. In response to the socio-economic consequences of unification and European integration, German planning has experimented with new regional associations. In the US, concerns over sprawl have led to increased state-level planning and intervention. We conclude that these trends are in response to different circumstances and are subject to different institutional constraints.