CARCINOMA of the floor of the mouth is a clinical an epithelioma varying in degree of keratinization entity only in its early stages. Involvement of and anaplasia; it is either an exuberant mass or adjacent structures is common and soon the disease an ulcer with indurated edges. The disease is spreads beyond the floor itself. considered as in three directions-to the intrinsic patients, many tumours develop in edentulous and extrinsic muscles of the tongue, to the gum mouths. The usual so-called precancerous changes with or without involvement of the alveolus, and such as leucoplakia, chiefly of the floor itself and to the cervical lymph-glands. Although such a of the gingival mucosa, are frequently seen. All subdivision is artificial it is of help in considering these features are well known and require no the choice of treatment and in the planning thereof emphasis. (Fig. 267).
Inherited coagulopathies are reported in a number of dog breeds. However, to date, there is no report of Weimaraners suffering factor VIII deficiency (haemophilia A). We report the discovery of haemophilia A in both males from a single litter of Weimaraners. Haemophilia A in human beings often results from a de novo stochastic mutation. We found no evidence using currently available screening tests of haemophilia A in relatives as far back as three generations making a stochastic mutation possible in this litter.
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