The role of adrenalectomy in cancer of the breast

Cade, Stanford

doi:10.1002/1097-0142(195707/08)10:4<777::aid-cncr2820100424>3.0.co;2-d

Cited by 27 publications

(6 citation statements)

References 5 publications

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“…to Cade(1957),there was scarcely any difference between the efficacies before and after the menopause.In the present series, the rate of improvement seemed to be somewhat higher for the patients after the menopause.…”

Section: Clinical Resultsmentioning

confidence: 91%

Effects of Castration and Adrenalectomy on the Advanced Mammary Cancer

et al. 1959

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Many sorts of hormones such as estrogens have been reported as the factors accelerating the development of mammary cancer. In consequence, methods to block such accelerating factors in the advanced mammary cancer, that is, castration, adrenalectomy and hypophysectomy have been attempted as the therapy of the advanced mammary cancer. Since Atkins(1957)and Huggins and Bergenstal (1951)for the first time conducted the total adrenalectomy on patients with advanced or metastasizing mammary cancer, nearly 1, 000 instances of this kind of therapy have been reported in the world literature by the end of 1958. In September 1953, we commenced ovariectomy and total adrenalectomy as a therapy for the metastasizing mammary cancer, treating 34 cases by December 1958. The subjects of the operation were patients between 37 and 67 years of age with mammary cancer of advanced stage, the metastasis being demonstrated in the lymph gland, the skin, the liver, the lung, the bone and the brain. In these operations, ovariectomy or castration by irradiation was performed as the first step, and then adrenalectomy was conducted. Some clinical results are hereby reported. RESULTS

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Section: Clinical Resultsmentioning

confidence: 91%

Effects of Castration and Adrenalectomy on the Advanced Mammary Cancer

et al. 1959

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“…Cade (1957) reported 158 patients with objective improvement in 39 per cent and subjective improvement in 58 per cent. Fraccia, Randall and Farrow (1967) reported a series of 500 consecutive adrenalectomies with an overall remission rate of 35 per cent.…”

Section: Oophorectomymentioning

confidence: 99%

Bilateral Adrenalectomy for Advanced Carcinoma of the Breast

Owen-Smith

1972

J R Army Med Corps

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A series of 27 bilateral adrenalectomies for advanced breast carcinoma is described. The ages of the patients ranged from 26 to 53 years and 16 were below the age of 40.Seven (28 per cent) did not respond and died on average after 5 months.Eighteen (72 per cent) responded. Of these, 9 died after an average of 22 months (2 lived more than 3 years) and 9 are still alive 1 to 3 years after operation.The development of the operation is described and the results compared with alternative palliative procedures.

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“…6 However, since over half the patients subjected to adrenalectomy receive no benefit and are subject to the unpleasant metabolic effects of adrenal removal in the face of advancing disease, the operation has been abandoned as a routine procedure by some clinics.7…”

Section: Introductionmentioning

confidence: 99%