Objectives: To assess and compare the concentration of leptin in saliva between normal weight and overweight individuals and to evaluate the rate of orthodontic tooth movement. Materials and Methods: Thirty female subjects were divided into two groups: I (normal weight) and II (overweight group) based on their body mass index. All subjects underwent fixed appliance therapy requiring upper first premolar extraction and distal movement of the canine. Distal force was applied to the maxillary right canine using active lacebacks. Salivary samples were collected just before force application (T 0 ), 1 hour (T 1 ), and 1 month (T 2 ) after force application. The rate of tooth movement was evaluated over 3 months and was measured on study models.

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Background The aim of this trial was to comparatively evaluate Icon® resin infiltration and Clinpro™ XT varnish in restoring aesthetics of white spot lesions (WSLs) present post-orthodontic treatment. Materials and methods Two hundred forty WSLs were detected in 193 teeth of 12 patients. The participants were analysed—before intervention (T 0 ), immediately after intervention (T 1 ), 3 months later (T 2 ) and 6 months later (T 3 ), with a 1:1 allocation ratio for the application of Icon® resin infiltration and Clinpro™ XT varnish. Using a computer-generated allocation sequence, block randomization was done. A spectrophotometer was used to assess the colour of WSLs and the adjacent enamel, while a DIAGNOdent® was used to assess the fluorescence loss. Results Immediately after the intervention, Icon® resin infiltration showed statistically significant better improvement than Clinpro™ XT varnish in restoring the colour ( p = 0.000); however, at 3 ( p = 0.001) and 6 months ( p = 0.000), this was reversed. Except at 3 months, the fluorescence loss sequentially reduced more for Icon® resin infiltration (4.48 ± 1.42 at T 0 to 1.48 ± 0.81 at T 3 ) and was not statistically significant. Conclusions Clinpro™ XT varnish showed significantly better improvement than Icon® resin infiltration in restoring the colour and lightness of the WSLs at 3 and 6 months. The fluorescence loss significantly recovered with both intervention methods between immediate application and at 6 months. However, Clinpro™ XT varnish-treated WSLs showed a statistically significant difference compared to the adjacent sound enamel at 6 months.

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Objectives:To test the hypothesis that there is no difference in the cytotoxicity related to the modes of polymerization of five commercially available orthodontic bonding resins, with and without an oxygen-inhibited layer (OIL), and to evaluate the degree of conversion (DC) of these resins and correlate this to cytotoxicity. Materials and Methods: Five commercially available orthodontic bonding resins were tested for cytotoxicity and DC. Thirty-six disks of standardized dimensions, for each resin, were used for cytotoxicity assessment. Half of them were washed with 99% acetone to remove the OIL (washed resins), and the remaining disks were left intact (intact resins). Glass disks were used as a control. Vero cells were exposed to intact and washed resins on day 1. Cell viability was determined by tetrazolium bromide reduction assay 1, 3, and 6 days after exposure. The DC of the adhesive specimens of each resin, prepared with a procedure identical to the clinical bonding process, was assessed by Fourier transform infrared spectroscopy. Results: Single-cured systems were comparatively less cytotoxic than dual-cured systems. With removal of the OIL, increased cell viability was noted only with two resins on all three days. Resins tested showed differences in DC. A positive correlation was demonstrated by two resins. Conclusion:The hypothesis is rejected. Single-cured systems are superior to dual-cured systems in exhibiting comparatively less toxicity and higher DC. A significant positive correlation was not established between cytotoxicity and DC.

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