In-vivo evaluation of salivary nickel and chromium levels in conventional and self-ligating brackets

Sahoo, Nivedita; Kailasam, Vignesh; Padmanabhan, Sridevi; Chitharanjan, Arun B

doi:10.1016/j.ajodo.2010.05.022

Cited by 29 publications

(39 citation statements)

References 25 publications

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“…In group 1, only ten subjects were treated with conventional (MBT preadjusted edgewise brackets) fixed appliance system and additional ten patients received self-ligating (SmartClip TM ) fixed appliance system (group 2). Both groups had 16 brackets, four bands as well as 0.016 inch NiTi wires (3M Unitec) and unstimulated saliva samples were collected 1 hour before, 1, 7 and 30 days after placement of appliances [40]. In contrast to our investigation, the authors used an atomic absorption spectrometer to determine Ni +2 levels in patients` saliva [40].…”

Section: Discussionmentioning

confidence: 99%

“…Both groups had 16 brackets, four bands as well as 0.016 inch NiTi wires (3M Unitec) and unstimulated saliva samples were collected 1 hour before, 1, 7 and 30 days after placement of appliances [40]. In contrast to our investigation, the authors used an atomic absorption spectrometer to determine Ni +2 levels in patients` saliva [40]. Atomic absorption spectrometer has a higher detection threshold and inferior resolution than inductively-coupled plasma mass spectrometry [5,27,37,38,44].…”

Section: Discussionmentioning

confidence: 99%

“…Ni content ranging between 5% and 55% ( and chromium concentrations in twenty women divided in two groups [40]. In group 1, only ten subjects were treated with conventional (MBT preadjusted edgewise brackets) fixed appliance system and additional ten patients received self-ligating (SmartClip TM ) fixed appliance system (group 2).…”

Section: Discussionmentioning

confidence: 99%

“…Apart from the possible additional release of Ni +2 from the clip, this clip also enables an active and constant surface proximity between wire and bracket components which may result in increasing Ni +2 levels in-vivo. However, to date only one study has investigated the release of self-ligating fixed appliances in-vivo using ten patients in the group with self-ligating brackets [40].…”

Section: Methodsmentioning

confidence: 99%

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Nickel ion concentrations in the saliva of patients treated with self-ligating fixed appliances: a prospective cohort study

et al. 2016

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OBJECTIVE Orthodontic appliances are considered to be highly biocompatible although adverse effects attributed to the release of nickel ions (Ni(2+)) have been documented. Self-ligating brackets have grown in popularity for economic reasons and supposed friction reduction. The aim of the present prospective cohort study was therefore to determine salivary Ni(2+) concentrations in patients undergoing orthodontic treatment with self-ligating fixed appliances. MATERIALS AND METHODS A group of 30 patients between 10 and 13 years of age were treated with self-ligating brackets (SmartClip™), molar bands, and nickel-titanium (NiTi) archwires. Unstimulated saliva samples were collected after different time points (before treatment, after self-ligating bracket and band placement, before archwire insertion, after archwire insertion, and finally 4 and 8 weeks afterwards) and analyzed with an ICP mass spectrometer followed by generalized estimating equation modelling with = 5 %. RESULTS The baseline median salivary Ni(2+) concentration was 21.85 µg/l, while the Ni(2+) concentrations at the following visits ranged between 13.73 and 85.34 µg/l. Significant increases in Ni(2+) levels compared to the baseline levels were detected after band/bracket placement [+59.76 µg/l; 95 % confidence interval (CI) 44.88-74.64 µg/l; P < 0.001] and after archwire insertion (+53.55 µg/l; 95 % CI 25.57-81.52 µg/l; P < 0.001). After 4 weeks, Ni(2+) concentrations returned to initial control levels or were lower. CONCLUSION Self-ligating orthodontic appliances may affect salivary Ni(2+) concentrations in vivo over the short term. However, levels resembled those documented in conjunction with conventional bracket use and remained below the daily dietary Ni intake. 2 Abstract Background and objective: Orthodontic appliances are considered to be highly biocompatible,

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Nickel ion concentrations in the saliva of patients treated with self-ligating fixed appliances: a prospective cohort study

et al. 2016

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“…Así, con la administración de acetato tetrahidrato de Ni, hexahidrato de cloruro de Ni, sulfamato tetrahidratado de Ni y hexahidrato sulfato de Ni, con una dosis dese puede concluir que existe un leve aumento de liberación de níquel en los primeros días de tratamiento que se va reduciendo progresivamente con el tiempo (i.e. contenido de níquel en saliva de sujetos con ortodoncia de 18.5 ± 13.1 ng/mL frente a valores de 11.9 ± 11.4 ng/mL en sujetos control) (Amini, Jafari, Amini, & Sepasi, 2012;Karnam, Naveen, & Manjith, 2012;Mikulewicz & Chojnacka, 2010;Sahoo, Kailasam, Padmanabhan, & Chitharanjan, 2011). A pesar de ello, no se ha descrito que lleguen a alcanzarse niveles tóxicos; aún así es recomendable efectuar este tipo de estudios sobre todo, en pacientes con alergias en las que podría estar implicado el Ni (Navarro & Gil, 2010).…”

Section: Estudios De Biodisponibilidad In Vivounclassified