Salivary leptin levels in normal weight and overweight individuals and their correlation with orthodontic tooth movement

Abstract

Objectives: To assess and compare the concentration of leptin in saliva between normal weight and overweight individuals and to evaluate the rate of orthodontic tooth movement. Materials and Methods: Thirty female subjects were divided into two groups: I (normal weight) and II (overweight group) based on their body mass index. All subjects underwent fixed appliance therapy requiring upper first premolar extraction and distal movement of the canine. Distal force was applied to the maxillary right canine using active lacebacks. Salivary samples were collected just before force application (T 0 ), 1 hour (T 1 ), and 1 month (T 2 ) after force application. The rate of tooth movement was evaluated over 3 months and was measured on study models.

Salivary protein biomarkers associated with orthodontic tooth movement: A systematic review

“…However, it is unknown if MPO will change every time fixed appliance is activated and if so by how much. Similar trends were shown in leptin . Leptin, depending on body weight, can also have large individual variation.…”

“…Only one study attempted to have an equal amount of males and females . Two studies chose to only include female subjects . Multiple time points were commonly used.…”

“…Two types of studies were found: targeting and non‐targeting studies (Table ). The targeting studies used known proteins such as sRANKL/OPG, MPO activity and leptin . ELISA and enzymatic activity assay were used to study these known biomarkers.…”

Association between obesity and adipokines levels in saliva and gingival crevicular fluid: A systematic review and meta‐analysis

“…22,[24][25][26]33,36,37,[39][40][41][42]45,[47][48][49][50]55,[57][58][59]61 Three articles included children, adolescents, and adults. 38,46,52 Among the 34 included articles, 18 different adipokines were analyzed. Evaluation of adipokines in saliva was carried out in 17 articles.…”

“…Evaluation of adipokines in saliva was carried out in 17 articles. 21,33,34,[36][37][38]41,[45][46][47][48]51,55,[57][58][59]61 Analysis of GCF was performed in 15 articles. [22][23][24]26,35,39,40,[42][43][44]49,50,[52][53][54] Two studies 25,56 evaluated adipokines in both saliva and GCF.…”