Introduction: Genetic polymorphisms in codons 10 of the transforming growth factor β1 (TGF-β1) gene TGFB1 have been shown to be associated with the production of high or low TGF-β1 levels. The role of this polymorphism in the development of prostate cancer and hyperplasia was investigated. Subjects and Methods: Using the allele-specific oligonucleotide polymerase chain reaction method, the association between the polymorphism at codon 10 of the TGFB1 gene and the risk of prostate cancer (PCa) or benign prostate hyperplasia (BPH) was determined. Results: Significant differences in the CC versus TT genotype distribution between PCa patients and male controls (p = 0.009), and between BPH patients and male controls (p = 0.005) were noted. Males with the TT genotype had a 1.67-fold increased risk of PCa and those with the TC/TT genotype had a 1.14-fold increased risk of PCa; males with the TT genotype had a 1.54-fold increased risk of BPH and those a with the TT/TC genotype had a 1.06-fold increased risk of BPH compared with those with the CC genotype. Conclusions: Based on our findings, it was possible to conclude that the codon 10 polymorphism in TGFB1 may have a significant influence on the development of PCa and BPH and that the T allele of the TGFB1 gene has a dominant effect on the development of PCa and BPH.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.