Background: The occurrence of occupational lung diseases is decreasing due to improvements in occupational health in recent years; however, silicosis and its complications remain important occupational health problems. We have studied the role of emphysema and bullae as predictive factors of secondary spontaneous pneumothorax in acute and accelerated silicosis.

In this study, it was determined whether the IL-10 -1082, IFN-gamma +874, and TNF-alpha -308 polymorphisms were associated with suicidal behavior. One hundred forty five patients with suicidal behavior and 160 normal individuals were genotyped for IL-10 -1082, IFN-gamma +874, and TNF-alpha -308 polymorphisms using ASO-PCR method. TNF-alpha -308 G/G genotype has been increased in males with completed suicide behavior versus control group (p value = 0.017). IL-10 -1082 A/A genotype is higher in both male and female suicide completed groups (p value = 0.017). IFN-gamma (+874) A/A genotype was significantly higher in males with completed suicide behavior versus normal male control (p value = 0.027). It can be concluded that IL-10, IFN-gamma, and TNF-alpha polymorphisms may play a role in suicidal behavior.

Introduction: Genetic polymorphisms in codons 10 of the transforming growth factor β₁ (TGF-β₁) gene TGFB1 have been shown to be associated with the production of high or low TGF-β₁ levels. The role of this polymorphism in the development of prostate cancer and hyperplasia was investigated. Subjects and Methods: Using the allele-specific oligonucleotide polymerase chain reaction method, the association between the polymorphism at codon 10 of the TGFB1 gene and the risk of prostate cancer (PCa) or benign prostate hyperplasia (BPH) was determined. Results: Significant differences in the CC versus TT genotype distribution between PCa patients and male controls (p = 0.009), and between BPH patients and male controls (p = 0.005) were noted. Males with the TT genotype had a 1.67-fold increased risk of PCa and those with the TC/TT genotype had a 1.14-fold increased risk of PCa; males with the TT genotype had a 1.54-fold increased risk of BPH and those a with the TT/TC genotype had a 1.06-fold increased risk of BPH compared with those with the CC genotype. Conclusions: Based on our findings, it was possible to conclude that the codon 10 polymorphism in TGFB1 may have a significant influence on the development of PCa and BPH and that the T allele of the TGFB1 gene has a dominant effect on the development of PCa and BPH.

Background:The occurrence of occupational lung diseases is decreasing due to improvements in occupational health in recent years; however, silicosis and its complications remain important occupational health problems. We have studied the role of emphysema and bullae as predictive factors of secondary spontaneous pneumothorax in acute and accelerated silicosis.Materials and Methods:This study was carried out using questionnaire items on occupational history and conventional computed tomography of lungs. Differences between two groups (silicosis with and without secondary spontaneous pneumothorax) in terms of age, interval of exposure-diagnosis and therefore silica exposure duration were assessed by independentt -test. Fisher’s exact test was used to determine the association between secondary spontaneous pneumothorax and both emphysema and bullae.Results:We found a significant association between secondary spontaneous pneumothorax and bullae in acute and accelerated silicosis.Conclusion:Pneumothorax in silicosis could be attributed to previous bullae.