Association of Codon 10 Polymorphism of the Transforming Growth Factor Beta 1 Gene with Prostate Cancer and Hyperplasia in an Iranian Population

Abstract

Introduction: Genetic polymorphisms in codons 10 of the transforming growth factor β₁ (TGF-β₁) gene TGFB1 have been shown to be associated with the production of high or low TGF-β₁ levels. The role of this polymorphism in the development of prostate cancer and hyperplasia was investigated. Subjects and Methods: Using the allele-specific oligonucleotide polymerase chain reaction method, the association between the polymorphism at codon 10 of the TGFB1 gene and the risk of prostate cancer (PCa) or benign prostate hyperplasia (BPH) was determined. Results: Significant differences in the CC versus TT genotype distribution between PCa patients and male controls (p = 0.009), and between BPH patients and male controls (p = 0.005) were noted. Males with the TT genotype had a 1.67-fold increased risk of PCa and those with the TC/TT genotype had a 1.14-fold increased risk of PCa; males with the TT genotype had a 1.54-fold increased risk of BPH and those a with the TT/TC genotype had a 1.06-fold increased risk of BPH compared with those with the CC genotype. Conclusions: Based on our findings, it was possible to conclude that the codon 10 polymorphism in TGFB1 may have a significant influence on the development of PCa and BPH and that the T allele of the TGFB1 gene has a dominant effect on the development of PCa and BPH.

TGFB1 (transforming growth factor, beta 1)

“…However, an association between single nucleotide polymorphisms of TGFB1 at C-509T and a decreased risk of aggressive prostate cancer has been described (Brand et al, 2008). On the other hand, the codon 10 polymorphism in TGFB1 may have a significant influence on the development of prostate cancer and benign prostatic hyperplasia (Omrani et al, 2009). …”

Evaluation of interleukin-17 receptor (IL-17RA) gene expression in PBMCs of patients with premature coronary artery disease

“…Numerous infl ammatory cytokines contribute in every part of atherosclerosis (17)(18)(19)(20)(21)(22)(23)(24)(25). In this regard, the roles of chemoattractants including chemokine 2 (CCL2) and CCL5, which promote the recruitment of monocytes (18), as well as secretion of pro-infl ammatory cytokines: IL-1 β, IL-6, and TNF-α in NF-κB signaling in infl ammation (19) have been identifi ed.…”

Association Between Head and Neck Cancers and Polymorphisms 869T/C, 509C/T, and 915G/C of the Transforming Growth Factor-β1 Gene: A Meta-Analysis of Case-Control Studies

“…The functions of TGF-β1 are inhibited during the late stages of cancer due to the inactivation of tumor suppressor gene P53 and alterations in the TGF-β1 signaling pathway, resulting in tumor cell invasion and metastasis [25–27]. Previous studies have reported an association between polymorphisms of the TGF-β1 gene and carcinogenesis in NPC [28], lung cancer [29], esophageal cancer [30], prostate cancer [31], colon cancer [32], and gastric cancer [33]. TGF-β1 gene polymorphisms have been reported to be associated with the occurrence and progression of HNSCC [34].…”