Efficient detection of arsenate (AsO43-) from contaminated drinking water extracted from underground becomes a matter of utmost necessity as well as exquisite challenge owing to on growing public health damage...
Two architecturally dissimilar coordination complexes, namely, C1 = [CuL 1 (NO 2 )] 2 and C2 = [CuL 2 (NO 3 )] (L 1 = (4-bromo-2-[(2-isobutylaminoethylimino)methyl]phenolate and L 2 = (4-bromo-2-[(2-propylaminoethylimino)methyl]phenolate) have been synthesized from two different organic ligand backbones. The synthesized complexes have been identified using some common techniques like elemental analysis, FT-IR spectroscopy, and single-crystal X-ray analysis. The X-ray structural analysis revealed that C1 is a dinuclear complex realized through one bridging nitrite anion, whereas for C2, nitrate anions bridge the complexes to accomplish a 1D coordination polymer. C1 and C2 when slashed down by rapid and green mechanical method by using a simple hand grinding technique, mortar and pestle, resulted in NC1 and NC2 nanoparticles, whose average size was characterized by PXRD, SEM, and DLS. As far as we know, this is the first report where the nano-formulation has been used while maintaining the structural integrity of the Schiff base complex. The proliferative properties of these complexes have been assessed in vitro using human lung carcinoma cell line A549. Being a polymer, the number of metal centers in NC2 is much higher; accordingly, this complex is more vital in terms of biological activity in comparison with NC1.
This work delivers a targeted synthesis of four isostructural O-substituted imidazole-based zinc(II) complexes, namely, [Zn 2 (L 1 ) 2 (I) 2 ](DMF) (1), [Zn 2 (L 2 ) 2 (I) 2 ](DMF) (2), [Zn 2 (L 1 ) 2 (Br) 2 ] (3), and [Zn 2 (L 2 ) 2 (Br) 2 ] (4), derived from homologous Schiff-base ligands HL 1 and HL 2 to explore their impact on free radicals, microbes, and dephosphorylation of phosphoesters. The antioxidant activity of all complexes was checked by various radical scavenging assays (ABTS +• , DPPH • , and H 2 O 2 radical quenching). Among them, complex 2 showed superior radical quenching activity, as indicated by its lowest EC50 value and thus maximum antioxidative capability. Again, antibacterial assays against several Gram-positive and Gramnegative bacteria were conducted to evaluate the zone of inhibition. The minimum bactericidal concentration and minimum inhibitory concentration values from the microdilution method for all complexes revealed complex 3 to have maximum potency against Gram-positive bacteria. The P−O bond hydrolysis in the phospholipid chain caused by the hydrolytic phosphoesterase activity of the Zn(II)-complexes plays a crucial role in cell membrane rupture. A model substrate 4-PNPP was used to explain the potency of monomeric Zn(II) complex (3) for cell penetration over dimeric one (2) with a proper mechanism. Furthermore, a heme model substrate, Fe(TPP)Cl, has been introduced with the most potent complex 3 and has spectrophotometric evidence for covalent interaction with imidazole and Fe(III) that can disrupt the nitric oxide dioxygenase function of flavohemoglobin, leading to bacterial cell death. To our knowledge, this is the first case to report a novel mechanism of antimicrobial action where both the metal and the ligand are cooperatively involved in bacterial cell death. The main goal of this work is to invent multifunctional therapeutics as well as the proper chemical rationalization of biological processes using mechanistic approaches, which includes investigating the roles of halides, imidazoles, and solution-phase structural variations of complexes..
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