An effortless approach to synthesize two structurally diverse nano copper(II) materials and assessment of their apoptosis‐inducing ability on lung cancer cell line

Abstract

Two architecturally dissimilar coordination complexes, namely, C1 = [CuL 1 (NO 2 )] 2 and C2 = [CuL 2 (NO 3 )] (L 1 = (4-bromo-2-[(2-isobutylaminoethylimino)methyl]phenolate and L 2 = (4-bromo-2-[(2-propylaminoethylimino)methyl]phenolate) have been synthesized from two different organic ligand backbones. The synthesized complexes have been identified using some common techniques like elemental analysis, FT-IR spectroscopy, and single-crystal X-ray analysis. The X-ray structural analysis revealed that C1 is a dinuclear complex realized through one bridging nitrite anion, whereas for C2, nitrate anions bridge the complexes to accomplish a 1D coordination polymer. C1 and C2 when slashed down by rapid and green mechanical method by using a simple hand grinding technique, mortar and pestle, resulted in NC1 and NC2 nanoparticles, whose average size was characterized by PXRD, SEM, and DLS. As far as we know, this is the first report where the nano-formulation has been used while maintaining the structural integrity of the Schiff base complex. The proliferative properties of these complexes have been assessed in vitro using human lung carcinoma cell line A549. Being a polymer, the number of metal centers in NC2 is much higher; accordingly, this complex is more vital in terms of biological activity in comparison with NC1.

UV-assisted photochemical transformation of a tetranuclear copper(ii) complex: a DFT supported study on β-lactamase inhibitory activity towards antibiotic resistance

“…34,35 blue shifting of the above transition is observed. 36 In this present case, C1 shows a typical high-energy strong band near λ max ∼ 279 nm( ε = 4355 L mol −1 cm −1 ) assigned to the metal → ligand charge transfer along with a weak low-energy band at λ max ∼ 677 nm ( ε = 93 L mol −1 cm −1 ) mainly due to d–d transitions ( 2 E g → 2 T 2g ). 37 To elucidate the solution phase structure, the electrospray ionization mass spectrometry of complex C1 was recorded in aqueous methanolic solutions in a positive mode (Fig S3, in the ESI†).…”

Biochemical Resistivity against Free Radicals and Microbes: Cooperative Action of Zn(II)/Imidazole in Phosphoesterase-Mediated Cell Death

“…Antioxidants help inhibit or delay oxidative stress by radical scavenging action. It is necessary to explore the role of naturally occurring intracellular antioxidants and invent novel antioxidant nutraceuticals to combat several free radical-mediated ailments like inflammation, aging, cancer, and so forth. – Furthermore, the development of potential antibiotics, antivirals, antiparasitics, and antifungals also remains an unmet medical need. , These chemicals must be capable of regulating at least one of the six possible mechanisms of antimicrobial action that include: (1) interrupting bacterial cell wall synthesis, (2) impeding membrane function, (3) restraining protein synthesis, (4) metabolic dysfunction, (5) interfering in nucleic acid synthesis, and (6) inhibition of ATP synthase …”