In this study, liquid phase oxidation of ethyl benzene to acetophenone was widely investigated using a new recyclable supported catalyst of CuO –nanoparticles impregnated over activated red–mud (CuO_AARM). The catalyst was...
Conversion of olefin to epoxide: Surface acidic sites of the catalysts allow the electron rich olefin to get adsorb on the catalyst and facilitate the bond cleavage to form epoxides.
This pandemic situation has made us to understand that we need to have look for more potential anti-viral agents in order to combat the SARS virus. During this period many existing anti-viral agents are directly being used to find their efficacy or being modified to increase their efficacy. In an ongoing effort to discover a noble series of imidazole-based epoxides, which can act as synthon for the synthesis of β-Amino alcohols, were designed and synthesized using a mild, efficient, and metal free approach starting from N1-hydroxy-2,4,5-trisubstituted-imidazoles and epichlorohydrin as precursor compound which may have higher potential to show biological activity. To support the experimental finding, we have performed Density Functional Theory (DFT) calculation. On the basis of the experimental findings and theoretical calculation we have drawn the reaction pathway that led to the product formation.
In this study, Pt(II)-catalyzed intramolecular translocation
annulation
of ortho-alkynylamides to the formation of indoles
is presented, where a proposed intermediacy of zwitterionic intermediate
has been substantiated over the oxidative addition. We focused our
attention on Pt(II)-catalyzed aminoacylation of alkynes both theoretically
and experimentally using low boiling solvent where the formation of
deacylation product was suppressed simultaneously. One-step intramolecular
[1,3]-acyl migration from the zwitterionic intermediate is highly
unlikely, which imparts a high energy barrier of +99.0 kcal mol–1. Another possible approach involving oxidative addition
to the N–C bond, migratory insertion to alkyne, and subsequent
reductive elimination is also explored through DFT studies to justify
the reaction consequence. However, based on the computational studies,
it is suggested that initial zwitterion formation is highly favored
over oxidative addition. We suggest the formation of an acylium intermediate,
which can further react with indol-3-ylplatinum species in an intramolecular
manner, albeit within the same solvent cage to form 3-acyl indoles.
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