On 31 of July 2019, the Public Health Agency of Sweden was alerted about an increasing number of tularaemia cases in Gävleborg, a county in central Sweden. The number of cases increased thereafter peaking at about 150 reports of illnesses every week. As at 6 October, a total of 979 cases (734 laboratory-confirmed) have been reported, mainly from counties in central Sweden. The outbreak is now considered over (as at 14 October).
It is a challenge to differentiate between HIV-associated neurocognitive disorders (HAND) and other types of neurocognitive disease in the ageing HIV-infected population. Here we describe a 63 year old HIV-infected woman who had a history, neuropsychological test result, and PET examination consistent with characteristic Alzheimer’s disease (AD). The cerebrospinal fluid (CSF) biomarker profile was analogous to the profile typically found in AD in HIV-negative patients with increased t-tau and p-tau, a decreased level of Aβ42 and normal levels of CSF neurofilament light protein and sAPPα and sAPPβ, distinctly different from findings in HIV-associated dementia (HAD). Assessment of CSF biomarkers may be a valuable tool for clinicians to distinguish between HAD and AD.
In this report, we present the first known case of Bartonella endocarditis in Sweden. IgG antibody titres to Bartonella spp. were elevated but blood cultures remained negative. Sequencing of a gltA fragment from DNA extracted from heart valve tissue specimens revealed sequence homology with B. quintana.
The aim of this retrospective investigation was to study the occurrence, characteristics and outcome of culture-positive bacterial arthritis in a Swedish county hospital for the period 1994-97. Using registers of diagnosis, 15 adult patients with infectious arthritis in native joints were identified. Staphylococcus aureus was, as expected, the most common microbial agent. Six cases were caused by direct inoculation. The risk for bacterial arthritis caused by intra-articular steroid injection was estimated at 1/12,000. Joint damage was seen in 6 cases. Two patients died during the infection. White blood cell count in synovial fluid was performed in 5 cases, with median value 1.9 x 10(9)/l and, since it was not a good predictor of infection in this study, the value of this method for this indication is questioned.
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