A promising path for introducing rapid modulation into fibres would be through the piezoelectric effect [10][11] . Embedding piezoelectric domains would allow fibres to be electrically actuated over broad frequencies on the one hand, and to function as sensitive broadband microphones on the other. However, fibres for the most part have been made of materials in the disordered glassy state precluding the crystalline symmetry requirements necessary for piezoelectricity.Recent progress in drawing of fibres made of a multiplicity of materials 12 present new opportunities for re-examining this challenge. With this approach, fibre materials are drawn from 3 preforms in a regime dominated by viscous forces allowing for internal low viscosity domains to be arranged in non-equilibrium cross sections confined by viscous glassy boundary layers. In fact constructing a piezoelectric fibre could be accomplished in a straightforward manner by assembling a preform made of a piezoelectric material poly(vinylidene fluoride) (PVDF) 13-14 , with metal electrodes and an insulating polymer, which would be followed by a thermal draw.The stress present during the fibre draw should in principle induce the non-polar α to the ferroelectric β phase transition in the PVDF layer 13,[15][16] . The process should yield many metres of fibre with built-in internal electrodes which could be utilized to establish the large electric field necessary for poling the PVDF layer. However, upon detailed examination a number of significant challenges and seemingly conflicting requirements arise. The necessity to utilize crystalline materials both for the piezoelectric layer and the electrical conductors leads to the formation of multiple adjacent low viscosity and high aspect ratio domains. These domains undergoing a reduction in cross sectional dimensions are susceptible to capillary breakup and mixing during fibre drawing due to flow instabilities. Layer thickness non-uniformity either in the lateral or in the longitudinal directions [17][18] precludes the formation of the coercive field needed for poling. Moreover, even if capillary breakup were kinetically averted and uniform sections of fibres were to emerge they would not exhibit piezoelectricity because the stress and strain conditions necessary to induce the thermodynamic phase transition in PVDF cannot be sustained in the fibre draw process.To address these challenges we choose to focus our attention on the ability to maintain geometric coherence and layer thickness uniformity. A viscous and conductive carbon-loaded poly(carbonate) (CPC) is used to confine the low viscosity crystalline piezoelectric layer during 4 the draw process. The CPC layers exhibit high viscosity (10 5~1 0 6 Pa·s) at the draw temperature and adequate conductivity (1~10 4 ohm·m) over the frequency range from DC to tens of MHz, thus facilitating short range (hundreds of microns) charge transport on length scales associated with the fibre cross section. Then a piezoelectric polymer which crystallizes into the appropriate phase...

A thermal method for converting Au colloids into atomic Au clusters and subsequent growth of Au nanocubes from clusters is reported. Mass spectral analysis shows that these clusters are Au trimers. The Au clusters show distinct optical absorption at 305 and 250 nm and have extraordinary stability under ambient conditions.

We report new findings on the red fluorescent (λ = 640 nm) bovine serum albumin (BSA)-gold (Au) compound initially described by Xie et al. (J. Am. Chem. Soc. 2009, 131, 888-889) as Au nanoclusters. The BSA-Au compounds were further reducible to yield nanoparticles, suggesting that these compounds were BSA-cationic Au complexes. We examined the correlations between BSA conformations (pH-induced as well as denatured) and the resulting fluorescence of BSA-Au complexes, to understand the possible cationic Au binding sites. The red fluorescence of the BSA-Au complex was associated with a particular isoform of BSA, the aged form (pH > 10) of the five pH-dependent BSA conformations, while the other conformations, expanded (pH < 2.7), fast (2.7 < pH < 4.3), normal (4.3 < pH < 8), and basic (8 < pH < 10) did not result in red fluorescence. There could be internal energy transfer mechanisms to produce red fluorescence, deduced from excitation-emission map measurements. The ensemble minimum number of Au(III) per BSA to yield red fluorescence was <7. We illustrate the presence of multiple specific Au binding sites in BSA, and present an interpretation of the fluorescence of the BSA-Au complex, alternative to a single-site nucleation of a neutral Au nanocluster.

An imaging system has been developed based on pulses of Terahertz (THz) radiation generated and detected using all-optical effects accessed by irradiating semiconductors with ultrafast (fs-ps) pulses of visible laser light. This technique, commonly referred to as T-Ray Imaging or THz Pulse Imaging (TPI), holds enormous promise for certain aspects of medical imaging. We have conducted an initial survey of possible medical applications of TPI and demonstrated that TPI images show good contrast between different animal tissue types (muscle, fat, kidney, skin, cartilage). Moreover, the diagnostic power of TPI has been elucidated by the spectra available at each pixel in the image, which are markedly different for the different tissue types. This suggests that the spectral information inherent in TPI might be used to identify the type of soft and hard tissue at each pixel in an image and provide other diagnostic information not afforded by conventional imaging techniques.Preliminary TPI studies ofpork skin show that 3D tomographic imaging ofthe skin surface and thickness is possible, and data from experiments on models of the human dermis are presented which demonstrate that different constituents of skin have different refractive indices. Lastly, we present the first THz image of human tissue, namely an extracted tooth. The time of flight of THz pulses through the tooth allows the thickness of the enamel to be determined, and is used to create an image showing the enamel and dentine regions. Absorption of THz pulses in the tooth allows the pulp cavity region to be identified. Initial evidence strongly suggests that TPI may be used to provide valuable diagnostic information pertaining to the enamel, dentine, and the pulp cavity.

Using the finite-difference time-domain method we extract the effective optical constants of metallic nanoparticle arrays. We explore their behavior in the full range of filling fractions and find excellent agreement with the Maxwell-Garnett [Philos. Trans. R. Soc. London 203, 385 (1904)] effective medium theory for the effective dielectric constant. We also find that the resonance response of such systems exhibits an effective magnetic component, typically overlooked in standard effective medium theories. We verify that the description of these nanoarrays as an effective bulk medium is exact within numerical precision, at least in one-dimensional arrangements, by comparing with full simulations of more complex superlayer configurations. Finally, using the effective constants we study photonic crystal superstructures consisting of these arrays, demonstrating an interesting optical response where resonant absorption and reflection bands are separated by extremely sharp edges of almost 100% relative change per nanometer wavelength.

We revisit the prevailing hypothesis that the red fluorophore (λem = 640 nm) in the bovine serum albumin (BSA)–gold (Au) compound is a Au25 nanocluster. To examine the hypothesis, we investigated the kinetics of Au binding in this compound. In addition to the specific Au­(III) binding sites in BSA, we found a significant degree of nonspecific Au­(III) binding on the BSA surface. Time-course of the emergence of the red fluorescence was measured in detail for a range of pH, temperature, and concentration of Au­(III) with respect to BSA. The red fluorophore formation was a slow yet dynamic process, which was consistent with the pH-induced equilibrium transition in the conformation of BSA. Notably, the kinetic rate of the fluorophore formation was not strongly dependent on the concentration of Au­(III). Incorporating the existence of multiple specific and nonspecific binding sites, we propose a new model of the red fluorophore formation mechanism based on Langmuir-type adsorption of Au to BSA, as an alternative to the single-site nucleation model of Au25 nanoclusters.

An approach to image localized and propagating surface plasmon ͑SP͒ modes is introduced. It is shown that scanning tunneling microscope ͑STM͒-electroluminescence, the radiative decay of SPs induced by inelastically tunneling electrons, observed in Fourier space yields distinct features that reflect the degree of delocalization and spatial distribution of SP modes. The propagating SP is isolated from the localized mode by way of this Fourier space imaging approach. Furthermore, a cylindrically symmetric spatial interference pattern is obtained when the STM-induced plasmon is created within a circular ''corral'' boundary condition.

Cancer chemotherapy is typically toxic. This problem could be addressed by using differences between cancer and normal cells for controlled delivery of drugs to cancer cells. One such difference is the ubiquitously elevated glutathione expression in cancer cells. We report a simple and versatile synthesis of water-soluble gold nanoparticles passivated with amine-containing molecules, which allow for controlled drug release via ligand exchange with bio-available glutathione. Taking methotrexate-passivated gold nanoparticles (Au:MTX) as an example, drug delivery and controlled release via glutathione-mediated ligand exchange was evaluated. Furthermore, the possibility of using Au:MTX to improve therapeutic index in acute myeloid leukemia (AML) models was examined in vitro and in vivo. Au:MTX exhibited cancer selectivity in vitro. Au:MTX had an elevated potency toward an AML cell line THP-1 in a dosage range of 1-5 nM, and therefore an enhanced delivery of drug, whereas normal hematopoietic stem/progenitor cell (HSPC) growth was minimally affected by Au:MTX and MTX treatments within the same range of dosage. In vivo efficacy and safety of Au:MTX was evaluated in a murine xenotransplant model of primary human AML. Au:MTX treatment, compared to control groups including MTX-only and Au nanoparticle-only treatments, produced better leukemia suppression without added toxicity, indicating an enhanced therapeutic index.