The weakening of hard coal–rock mass is the core common problem that is involved in the top coal weakening in hard and thick coal seams, the hard roof control during the initial mining stage in the longwall mining face, and the hanging roof control in the gob of non-coal mine. Based on the characteristics of pulse hydraulic fracturing and constant pumping rate hydraulic fracturing, a weakening method for hard coal–rock mass by combining pre-pulse and constant pumping rate hydraulic fracturing is proposed. A complete set of equipment for the combined pulse and constant pumping rate hydraulic fracturing construction in the underground coal mine is developed. The pulse and constant pumping rate hydraulic fracturing technology and equipment were applied in the top coal weakening of the shallow buried thick coal seam. Compared with no weakening measures for top coal, the average block size of the top coal caving was reduced by 42% after top coal hydraulic fracturing. The recovery rate of the top coal caving mining face reached 85%, and it increased by 18% after hydraulic fracturing.
The purpose of this study was to investigate the combined effects of Ginkgo biloba extract and phenytoin (PHT) sodium as a dose regimen simulating the clinical treatment of patients with epilepsy, on P-glycoprotein (P-GP) overexpression in a pentylenetetrazole-kindled mouse model of epilepsy. Epilepsy was induced by intraperitoneal administration of pentylenetetrazole (40 mg/kg) for 7 days followed by intragastric administration of PHT (40 mg/kg) for 14 days. Thirty mice that developed seizures were randomly divided into three groups and administered PHT as well as the following treatments: saline (negative control); verapamil (20 mg/kg, positive control); and G. biloba (30 mg/kg). Seizure severity was recorded 30 minutes after treatment on Day 4 of drug administration, after which the mice were euthanized, and their brains isolated. Western blots and immunohistochemistry were performed to analyze the expression of P-GP and caspase-3, respectively, in the brain tissue. High-performance liquid chromatography was used to measure the concentrations of PHT in the brains of the treated mice. After 4 consecutive days of treatment, the seizure severity in the mice in the G. biloba extract group was more significantly reduced than the seizure severity in the saline control group, and a significant difference was observed between the G. biloba extract and verapamil control groups (p < 0.05). P-GP expression in the brain more significantly decreased in the mice treated with G. biloba extract and verapamil than it did in the saline-treated control group (p < 0.05). Compared with the saline-treated control group, the mice treated with G. biloba extract and verapamil showed significantly increased brain PHT concentrations (p < 0.05). Furthermore, caspase-3 expression in the brain tissue of the G. biloba extract group was significantly lower than that in the vehicle control group (p < 0.05); this finding demonstrated the neuroprotective effects of G. biloba. Therefore, this study showed that treatment with G. biloba extract in combination with PHT prevented the upregulation of P-GP expression in mice. Moreover, G. biloba extract decreased seizure severity in pentylenetetrazole-kindled/PHT-treated mice through a mechanism that might be related to the reduction of P-GP expression in the brain.
This paper describes the performance of 12 axially restrained RC columns (four for each type of cross section, i.e., +-, T-and L-shaped cross section) under fire conditions that were recently finished in South China University of Technology. The main objective of the paper is to investigate the effect of axial restraint on RC columns during both expanding and contracting phases. The RC columns were all initially concentrically loaded and subjected to ISO834 standard fire on all sides. Axial restraints were imposed at the top of the columns to simulate the restraining effect of the rest of the whole frame. Different degrees of axial restraint were obtained by varying the length of the restraining beam. The boundary conditions of the columns were considered as fixed-fixed for all tests. It is found that restrained RC columns behave quite differently to isolated ones. No typical 'runaway' failure of isolated RC columns was observed in the fire test. Finally, the finite element software, SAFIR, is employed to conduct a numerical analysis of the tests.
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