In this paper, we address component recovery under the condition of limited resources from the OEM's (Original Equipment Manufacturer's) standpoint. We develop a linear programming model for a hybrid remanufacturing and manufacturing system for production planning problems with deterministic returns. In this paper, a data set from an OEM that both remanufactures and manufactures the products is used to demonstrate the performance of the proposed model. Subsequently, an analysis of the impact of the remanufactured product's price and the quantity of returns on revenue and total cost will be discussed. We have found that uncertain factors of manufacturing influence the profit and uncertain factors of remanufacturing influence the production planning, such as the rate of the yield on component remanufacturing and the quantity of returns.
FIM protein, which consists of 155 amino acids, was developed as a novel GLP‐1 analog to reduce blood glucose, and pharmacodynamic results showed that it had a certain effect when used in treating Alzheimer's disease. The molecular weight of FIM is 16,304 Da. In theory, the concentration of FIM in biological samples should be determined by the ligand binding assay method or indirectly quantified using LC–MS/MS instrumentation. However, the above methods are complex and time‐consuming. In this study, we successfully developed a simpler LC–MS/MS method for directly quantifying the intact FIM protein in monkey plasma for the first time. The chromatographic separation of FIM was achieved using an InertSustain Bio C18 column with a mobile phase of acetonitrile containing 0.1% formic acid (A)–water containing 0.1% formic acid (B) at a flow rate of 0.3 ml/min. Good linearity was observed in the concentration range of 5–500 ng/ml (r2 > 0.99). The intra‐ and inter‐day precisions (expressed as relative standard deviation, RSD) of FIM were 2.30–12.8 and 7.30–13.2%, respectively. The intra‐ and inter‐day accuracies (expressed as a relative error, RE) were −12.7–6.55 and − 10.1–0.892%, respectively. This method was successfully applied for a pharmacokinetic study of the FIM protein in four monkeys after subcutaneous administration.
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