The aim of this study was to investigate the association of methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and additional gene-gene interaction with acute lymphoblastic leukemia (ALL) risk. Logistic regression was performed to investigate the association between two single nucleotide polymorphisms (SNPs) within MTHFR gene and ALL risk and additional gene-gene interaction between rs1801133 and rs1801131. The minor allele of rs1801133 and rs1801131 is associated with decreased ALL risk, OR (95% CI) were 0.61 (0.38-0.89), and 0.68 (0.50-0.96), respectively. We also found a significantly interaction between the two SNPs, participants with rs1801133 - CT or TT and rs1801131 - AC or CC genotype have the lowest ALL risk, compared with participants with rs1801133 - CC and rs1801131 - AA genotype, OR (95% CI) was 0.32 (0.12-0.63). We did not find any haplotype between the rs1801133 and rs1801131 associated with ALL risk. rs1801133 and rs1801131 within MTHFR gene and their interaction were both associated with ALL risk in Chinese children.
In this study, the complete mitochondrial genome (mitogenome) of the
Solenocera crassicornis
was amplified and analyzed. The mitogenome is 15,946 bp in length, encoding the standard set of 13 protein-coding genes, 22 tRNA genes and two rRNA genes. The overall A + T content is 67.67%; nucleotide frequency of the mitogenome is as follows: A, 32.00%; C, 11.14%; G, 21.19%; and T, 35.67%. There were 16 non-coding regions throughout the mitogenome of
S. crassicornis
ranged from 1 to 1,005 bp in size, of which the largest was between
tRNA
Ile
and
12S rRNA.
The complete mitogenome sequence information of
S. crassicornis
would play an important part for further studies on molecular systematics and phylogeny.
Ecological corridors (ECs) are important management tools to protect biodiversity by linking fragile habitats, especially for highly mobile organisms. ECs in terrestrial landscapes work as passages on land or in water. However, the significance of ECs to migratory species in estuaries has not been well elucidated. Based on annual fishery investigation in the Yangtze estuary and their dominance index rank, three of the top five species, including Larimochthys polyactis, Coilia mystus, and Gobiidae, exhibited absolute dominance in spring during the past 5 years. The temporal and spatial density variance of C. mystus supported its short-distance migration pattern. Redundancy analysis and the MaxEnt model predicted optimum habitats for C. mystus. C. mystus larvae survival was significantly related to salinity, total nitrogen, pH, reactive silicate, dissolved oxygen, surface water temperature, and chlorophyll-a in May and to salinity, surface water temperature, permanganate index, suspended particles, total nitrogen, and total phosphorus in August. The MaxEnt model predicted a broader longitudinal distribution range from offshore to the upstream freshwater area but narrower latitudinal distribution in the southern branch in May than in August. Finally, we delineated migratory corridors connecting optimum habitats for C. mystus using the least-cost route method. Optimum habitats close to the coastlines in the south branch might play a significant role in maintaining population or community connectivity in the Yangtze estuary. Our findings provide a perspective and method to quantify and facilitate the harmonious development of socioeconomy and fishery biodiversity conservation.
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