Association of methylenetetrahydrofolate reductase gene–gene interaction and haplotype with susceptibility to acute lymphoblastic leukemia in Chinese children

Xia, Xiaojun; Duan, Yun; Cui, Jie; Jiang, Junfeng; Lin, Li; Peng, Xiaojuan; Wang, Yuhong; Bingtao, Guo; Liu, Shouhai; Lei, Xudong

doi:10.1080/10428194.2016.1265117

Cited by 5 publications

(2 citation statements)

References 25 publications

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“…Totally 66 studies were included in the present meta-analysis regarding the relationship between C677T polymorphism of MTHFR gene and ALL. 1,5,9–68…”

Section: Resultsmentioning

confidence: 99%

Assessment of the relationship between methylenetetrahydrofolate reductase polymorphism and acute lymphoblastic leukemia: Evidence from an updated meta-analysis

Frikha

2020

J Oncol Pharm Pract

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Objective The methylenetetrahydrofolate reductase gene C677T polymorphism is closely related to the acute lymphoblastic leukemia. Several case–control studies have investigated this association; however, no conclusions could be drawn. A comprehensive updated meta-analysis is established to explain these contradictions and clarify the overall impact of this variant on the susceptibility to acute lymphoblastic leukemia. Methods Electronic searches were conducted to select published studies prior to June 2018. Pooled odds ratios and stratification analysis were performed under different genetic comparison models, age, and ethnicity. Results Totally, 66 case–control studies including 9619 acute lymphoblastic leukemia cases and 17,396 controls were selected. Our analyses showed that methylenetetrahydrofolate reductase C677T polymorphism was protective mainly in Asian and European countries, under all genetic models and regardless of age, but leukemogenic in mixed population. Conclusion Thus, C677T polymorphism may be a promising acute lymphoblastic leukemia biomarker, but they should be interpreted with caution considering other factors such as folic acid intake, gene–gene and gene–environment interactions.

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“…Totally 66 studies were included in the present meta-analysis regarding the relationship between C677T polymorphism of MTHFR gene and ALL. 1,5,9–68…”

Section: Resultsmentioning

confidence: 99%

Assessment of the relationship between methylenetetrahydrofolate reductase polymorphism and acute lymphoblastic leukemia: Evidence from an updated meta-analysis

Frikha

2020

J Oncol Pharm Pract

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“…Polymorphisms of the methylenotetrahydrofolate reductase ( MTHFR ) and methylenetetrahydrofolate dehydrogenase 1 ( MTHFD1 ) genes are known to reduce the activity of the enzyme that is essential for folate bio-availability and metabolism [11,12]. The rs1801133 variant of the MTHFR gene and the rs2236225 variant of MTHFD1 have been widely investigated in relation to the modulation of the risk of ALL, in a number of different populations [12,13,22,23]. In the present study, the log-additive association models of both genes were associated with a protective effect for the development of B-cell ALL ( MTHFR : OR = 0.399; 95%CI = 0.277–0.571; P < 0.001; MTHFD1 : OR = 0.546; 95%CI = 0.385–0.776; P < 0.001).…”

Section: Discussionmentioning

confidence: 99%

Association of genes ARID5B, CEBPE and folate pathway with acute lymphoblastic leukemia in a population from the Brazilian Amazon region

Carvalho

Wanderley

Mello

et al. 2020

Leukemia Research Reports

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Acute Lymphoblastic Leukemia (ALL) is the most common childhood neoplasia. Studies have shown that susceptibility to ALL may be modulated by genetic variables. Our study investigated 21 genetic variants in the susceptibility of the population of the Brazilian Amazon region to B-cell ALL. The variants of the genes GGH, CEBPE, ARID5B, MTHFR and MTHFD1 were related to a protective effect against the development of ALL, whereas the variant of the gene ATIC was associated with a risk effect. The results suggest that genetic variants analyzed modulate of the risk of developing ALL in the studied population.

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Interaction of MTHFR gene with smoking and alcohol use and haplotype combination susceptibility to psoriasis in Chinese population

et al. 2018

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To investigate the association of MTHFR gene polymorphism and additional gene-gene interaction with psoriasis risk. GMDR model was used to screen the best gene-smoking and gene-drinking interaction combinations. Logistic regression was performed to investigate association between two SNPs and psoriasis. For psoriasis patient-control haplotype analyses, the SHEsis online haplotype analysis software ( http://analysis.bio-x.cn ) was employed. We found that carriers of homozygous mutant of rs1801133 polymorphism and heterozygous of rs1801131 are associated with increased psoriasis risk than those with wild-type homozygotes, OR (95%CI) were 2.01 (1.48-2.79), and 2.08 (1.56-2.86), respectively. We also found a significant gene-environment interaction between C677T and alcohol drinking. In all samples, the haplotype 1298A-677C was observed most frequently in two groups, with 49.43 and 55.71% for the patients and controls, respectively. The results also indicated that the haplotype containing 1298C and 677T alleles were associated with a statistically increased psoriasis risk, OR (95%CI) = 1.73 (1.12-2.46), P = 0.0002. Our study found that rs1801133, rs1801131 within MTHFR gene, and interaction between C677T and alcohol drinking and haplotype containing the 1298C and 677T alleles were all associated with increased psoriasis risk.

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Association of methylenetetrahydrofolate reductase gene–gene interaction and haplotype with susceptibility to acute lymphoblastic leukemia in Chinese children

Cited by 5 publications

References 25 publications

Assessment of the relationship between methylenetetrahydrofolate reductase polymorphism and acute lymphoblastic leukemia: Evidence from an updated meta-analysis

Assessment of the relationship between methylenetetrahydrofolate reductase polymorphism and acute lymphoblastic leukemia: Evidence from an updated meta-analysis

Association of genes ARID5B, CEBPE and folate pathway with acute lymphoblastic leukemia in a population from the Brazilian Amazon region

Interaction of MTHFR gene with smoking and alcohol use and haplotype combination susceptibility to psoriasis in Chinese population

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