Interaction of MTHFR gene with smoking and alcohol use and haplotype combination susceptibility to psoriasis in Chinese population

Luo, Quan; Zeng, Jiayi; Wei, Li; Lin, Ling; Zhou, Xin; Xiang, Tian; Liu, Weiyu; Zhang, Lidan; Zhang, Xibao

doi:10.1007/s12026-018-9017-4

Cited by 9 publications

(7 citation statements)

References 20 publications

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“…Two previous meta-analyses were conducted, and no significant association of the MTHFR 677 C/T with the etiology of psoriasis was found [ 51 , 52 ]. It is necessary to update the data as many more studies appeared during the past years [ 31 , 42 , 44 , 45 , 53 ]. In this meta-analysis, we did not find any relationship of the SNP with psoriasis in overall comparison.…”

Section: Discussionmentioning

confidence: 99%

“…Not surprisingly, inconsistent results were also observed. Kilic et al reported that the prevalence of the 1298 C allele was higher by 17.0-fold in patients with psoriasis compared to the control group [ 31 ], whereas Luo et al reported that the genotype distribution of the 1298 A/C was not different significantly between psoriasis patients and controls [ 42 ]. In this meta-analysis, although a significantly increased association of the CC and AC/CC genotypes was observed in Asians, there was no significant relationship between the 1298 A/C and psoriasis risk in overall analysis and Caucasians.…”

Section: Discussionmentioning

confidence: 99%

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Association between Genetic Polymorphisms in Methylenetetrahydrofolate Reductase and Risk of Autoimmune Diseases: A Systematic Review and Meta-Analysis

Peng

et al. 2022

Disease Markers

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Methylenetetrahydrofolate reductase (MTHFR) is a critical rate-limiting enzyme in the homocysteine/methionine metabolism pathway that is implicated in the pathogenesis and progression of autoimmune diseases. Previous association studies have been performed to investigate the effect of polymorphisms in MTHFR on the risk of autoimmune diseases with inconsistent results. Therefore, this meta-analysis was designed to assess the association between the MTHFR 677 C/T and 1298 A/C polymorphisms and the susceptibility to autoimmune diseases. We identified reports by a literature search in the following electronic databases: PubMed, Ovid, Web of science, and China National Knowledge Infrastructure. Statistical analyses of the summary odds ratios (ORs) and 95% confidence intervals (CIs) were done using STATA software. In a recessive genetic model, the MTHFR 677 C/T polymorphism was associated with an increased risk of Behcet’s disease ( OR = 1.97 , 95% CI, 1.31-2.97), multiple sclerosis ( OR = 1.57 , 95% CI, 1.03-2.38), and ankylosing spondylitis ( OR = 2.90 , 95% CI, 1.92-4.38). The MTHFR 1298 A/C polymorphism was associated an increased risk of multiple sclerosis in a heterozygote comparison ( OR = 2.36 , 95% CI, 1.29-4.30) and in a dominant model ( OR = 2.31 , 95% CI, 1.24-4.29). This meta-analysis demonstrated that the MTHFR 677 C/T was a risk factor for Behcet’s disease, multiple sclerosis, and ankylosing spondylitis, and the 1298 A/C was a risk factor for multiple sclerosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association between Genetic Polymorphisms in Methylenetetrahydrofolate Reductase and Risk of Autoimmune Diseases: A Systematic Review and Meta-Analysis

Peng

et al. 2022

Disease Markers

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“…The association between MTHFR polymorphism and the susceptibility to psoriasis has been supported in Caucasians, Turkish, and Chinese populations ( 7 – 12 ). A study carried out in China reported that the rs1801133 T allele and the rs1801131 C allele were all associated with increased psoriasis risk ( 9 ). However, no studies have been found that surveyed the frequency of MTHFR polymorphisms in patients with PsA in the Han Chinese populations.…”

Section: Introductionmentioning

confidence: 99%

MTHFR Gene Polymorphism Association With Psoriatic Arthritis Risk and the Efficacy and Hepatotoxicity of Methotrexate in Psoriasis

et al. 2022

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AimsTo assess whether MTHFR rs1801131 and rs1801133 SNPs are associated with concomitant psoriatic arthritis (PsA) and investigate the efficacy and hepatotoxicity of MTX in patients with psoriasis in the Han Chinese population.MethodsThis prospective, single-arm, interventional study recruited a total of 309 patients with psoriasis, 163 with psoriatic arthritis and 146 without psoriatic arthritis, who completed a 12-week MTX treatment and 1,031 healthy controls. Patients' characteristics including age, gender, disease duration, height, weight, smoking status, alcohol consumption, medical history, disease severity and liver function test results were accessed and recorded. Single nucleotide polymorphism (SNP) genotyping of rs1801131 and rs1801133 in the MTHFR gene was performed.ResultsThe rs1801133 CC genotype was more frequent in patients with PsA than those with PsO and healthy controls (42.3% vs. 28.8% vs. 33.1%, p < 0.05). The 90% reduction from baseline PASI score (PASI 90) response rates to MTX were significantly higher in patients with the rs1801133 TT genotype than those with the CT and CC genotype (33.96% vs. 19.31% vs. 14.41%, OR = 2.76, p = 0.006). The rs1801133 CT+TT genotype was more frequent in PsA patients with abnormal liver function than in those with normal liver function (p < 0.05). In addition, patients with the rs1801131 CT genotype had lower PASI 75 response rates to MTX (OR = 0.49, p = 0.01), and lower risk of ALT elevation (OR = 0.46, p = 0.04).ConclusionsThis study provided some evidence for MTHFR polymorphism association with the risk of PsA and the efficacy and hepatotoxicity of the low-dose MTX in the Chinese population. Given the relatively small sample size and potentially missed diagnosis of PsA, the results from this study warrant further investigation.

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“…e pathogenesis of psoriasis is still not completely clarified. Present studies have suggested that autoimmune disorders, dysfunction in various inflammatory signal transduction pathways, abnormal expression of psoriatic susceptibility gene, and obesity might be involved in the pathogenesis of psoriasis [3][4][5][6][7][8][9]. e unknown pathogenesis has brought difficulties to the treatment, without curative approaches against psoriasis at present.…”

Section: Introductionmentioning

confidence: 99%

Investigation on the Mechanism of Qubi Formula in Treating Psoriasis Based on Network Pharmacology

Zhou

Zhang²,

Tao

2020

Evidence-Based Complementary and Alternative Medicine

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Objective. To elucidate the pharmacological mechanisms of Qubi Formula (QBF), a traditional Chinese medicine (TCM) formula which has been demonstrated as an effective therapy for psoriasis in China. Methods. The Traditional Chinese Medicine Systems Pharmacology (TCMSP) database, BATMAN-TCM database, and literature search were used to excavate the pharmacologically active ingredients of QBF and to predict the potential targets. Psoriasis-related targets were obtained from Therapeutic Target Database (TTD), DrugBank database (DBD), MalaCards database, and DisGeNET database. Then, we established the network concerning the interactions of potential targets of QBF with well-known psoriasis-related targets by using protein-protein interaction (PPI) data in String database. Afterwards, topological parameters (including DNMC, Degree, Closeness, and Betweenness) were calculated to excavate the core targets of Qubi Formula in treating psoriasis (main targets in the PPI network). Cytoscape was used to construct the ingredients-targets core network for Qubi Formula in treating psoriasis, and ClueGO was used to perform GO-BP and KEGG pathway enrichment analysis on these core targets. Results. The ingredient-target-disease core network of QBF in treating psoriasis was screened to contain 175 active ingredients, which corresponded to 27 core targets. Additionally, enrichment analysis suggested that targets of QBF in treating psoriasis were mainly clustered into multiple biological processes (associated with nuclear translocation of proteins, cellular response to multiple stimuli (immunoinflammatory factors, oxidative stress, and nutrient substance), lymphocyte activation, regulation of cyclase activity, cell-cell adhesion, and cell death) and related pathways (VEGF, JAK-STAT, TLRs, NF-κB, and lymphocyte differentiation-related pathways), indicating the underlying mechanisms of QBF on psoriasis. Conclusion. In this work, we have successfully illuminated that Qubi Formula could relieve a wide variety of pathological factors (such as inflammatory infiltration and abnormal angiogenesis) of psoriasis in a “multicompound, multitarget, and multipathway” manner by using network pharmacology. Moreover, our present outcomes might shed light on the further clinical application of QBF on psoriasis treatment.

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Interaction of MTHFR gene with smoking and alcohol use and haplotype combination susceptibility to psoriasis in Chinese population

Cited by 9 publications

References 20 publications

Association between Genetic Polymorphisms in Methylenetetrahydrofolate Reductase and Risk of Autoimmune Diseases: A Systematic Review and Meta-Analysis

Association between Genetic Polymorphisms in Methylenetetrahydrofolate Reductase and Risk of Autoimmune Diseases: A Systematic Review and Meta-Analysis

MTHFR Gene Polymorphism Association With Psoriatic Arthritis Risk and the Efficacy and Hepatotoxicity of Methotrexate in Psoriasis

Investigation on the Mechanism of Qubi Formula in Treating Psoriasis Based on Network Pharmacology

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