The release of the water-soluble drug Captopril is controlled by tailoring the surface properties of mesoporous silica via stepwise silylation. The degree of silylation is manipulated by adjusting the initial concentration of silylanizing reagent (trimethylchlorosilane, TMCS). The silylanized and drug-loaded samples are characterized by powder X-ray diffraction, Fourier transform IR spectroscopy, N2 adsorption and desorption, 29Si cross-polarization magic angle spinning NMR spectroscopy, and transmission electron microscopy. The drug-loading amount is correlated to the Brunauer-Emmett-Teller surface area and surface hydrophilicity/hydrophobicity of the mesoporous silica material, while drug release profiles can be controlled by tailoring the surface properties and pore size.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.