Controlled release of Captopril by regulating the pore size and morphology of ordered mesoporous silica

Silica Surface Features and Their Role in the Adsorption of Biomolecules: Computational Modeling and Experiments

“…for Captopril confined in the MCM-41 pores. 719 Consistently, the absorption bands of isolated SBA-15 at 3750 and 3630 cm -1 due to isolated and H-bonded silanol groups, respectively, became red-shifted in the ITR/SBA-15 system (see Figure 91d). However, according to the authors, such shifts were not only caused by the interaction with the C=O group but also by the interaction with the O ether and the N piperazine atoms, since significant spectral shifts in the CH stretching region of the neighboring ether and piperazine groups were also detected.…”

pH-controlled Release System for Curcumin based on Functionalized Dendritic Mesoporous Silica Nanoparticles

“…These results confirm that the curcumin release kinetics is dependent on the type of silica nanoparticles and the pH of release medium. Since the morphology structure of nanocarriers determine the interface between drug-loaded systems and the release medium, leading to influence the drug release kinetics [85][86][87][88]. It can be conclude that, mainly the delivery system of curcumin from both materials can be fitted to Higuchi model for MCM-NH2-Cur, and fitted to zero-order model for KCC-NH 2 -Cur.…”

Mesoporous drug carrier systems for enhanced delivery rate of poorly water-soluble drug: nimodipine

“…TEM images revealed significant differences in sizes and shapes of MCM-41 and SBA-15 matrices (Fig. 7) which could be ascribed to the difference in the length of pore channels [56]. Particles having short pore channels (i.e.…”