All methods left root canal filling material on the canal walls. Radiographic evaluation failed to detect the extent of remaining root filling material, which could only be detected using microscopy.
Antibiotic resistance has prompted the search for new
agents that
can inhibit bacterial growth. We recently reported on the antibiofilm
activities of nanosized ZnO and CuO nanoparticles (NPs) synthesized
by using sonochemical irradiation. In this study, we examined the
antibacterial activity of ZnO and CuO NPs in a powder form and also
examined the antibiofilm behavior of teeth surfaces that were coated
with ZnO and CuO NPs using sonochemistry. Free ZnO and CuO NPs inhibited
biofilm formation of Streptococcus mutans. Furthermore, by using the sonochemical procedure, we were able
to coat teeth surfaces that inhibited bacterial colonization.
The rapid advancement of peptide-and aminoacid-based nanotechnology offers new approaches for the development of biomedical materials. The utilization of fluorenylmethyloxycarbonyl (Fmoc)-decorated self-assembling building blocks for antibacterial and anti-inflammatory purposes represents promising advancements in this field.Here, we present the antibacterial capabilities of the nanoassemblies formed by Fmoc-pentafluoro-L-phenylalanine-OH, their substantial effect on bacterial morphology, as well as new methods developed for the functional incorporation of these nanoassemblies within resin-based composites. These amalgamated materials inhibit and hinder bacterial growth and viability and are not cytotoxic toward mammalian cell lines. Importantly, due to the low dosage required to confer antibacterial activity, the integration of the nanoassemblies does not affect their mechanical and optical properties. This approach expands on the growing number of accounts on the intrinsic antibacterial capabilities of self-assembling building blocks and serves as a basis for further design and development of enhanced composite materials for biomedical applications.
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