The reaction of in situ-generated thioamide dianions having a pyridylmethyl group on the nitrogen atom with thioformamides resulted in the formation of 5-H thiazoles as major products along with 5-N,N-dimethylaminothiazoles. The presence of a pyridylmethyl group plays an important role in the formation of 5-H thiazoles. A wide range of substituents at the 2-position of a thiazole ring tolerated the reaction conditions, and the intramolecular cyclization reaction proceeded smoothly. However, a phenyl substituent at the 4-position of a thiazole ring significantly reduced the yields of 5-H thiazoles.
Die mit RhC13/Äthanol katalysierte Reaktion von 2,7‐Octadienyl‐acetat (I) mit Butadien (II) führt zu den acetoxysubstituierten C12‐Trienen (III), (IV) und (V).
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